Development and validation of a musculoskeletal model of the pelvis in response to lateral impacts

响应横向冲击的骨盆肌肉骨骼模型的开发和验证

• 批准号: RGPIN-2015-03636
• 负责人: Laing, Andrew
• 金额: $ 1.75万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=656380
• 关键词: Development; validation; musculoskeletal; model; pelvis

My general field of interest is musculoskeletal biomechanics related to tissue loading, and the role that advanced age has on these relationships. Within this framework, the proposed program of research will generate novel insights into the basic mechanisms underlying dynamics of the pelvis during lateral impacts. For the 5-year horizon of the proposed grant, my short-term objectives are to characterize system state parameters of the body at the moment of impact initiation during lateral falls on the hip (Theme 1). This knowledge will inform the medium-term objectives of developing and validating a robust mathematical model that accurately predicts the loads applied to the pelvis during fall-related impacts. The initial stages of model development will focus on low-energy impacts from human volunteers (Theme 2). Specifically, 200 human participants will undergo low-energy sideways falls on the hip in a variety of body configurations. Data collected will include applied forces, pressure distribution, kinematics, and muscle activation levels. In addition, detailed skeletal geometry and body composition assessments will be conducted using dual x-ray absorptiometry, ultrasound, and body impedance analysis. The resulting data will be used to develop a mathematical model that accurately predicts the time-varying loads applied to the lateral pelvis during sideways falls on the hip. A variety of model types will be evaluated including: i) lumped-parameter; ii) Hertzian contact; and iii) multiple regression approaches. The most promising model will undergo initial validation using a subset of participant data. In Theme 3, cadavers (accessed through the University of Waterloo's School of Anatomy) will be used to further validate, or refine, the pelvic model of impact. In addition to replicating the low severity impacts performed by human volunteers, model validation will be extended to higher energy impacts more representative of worst-case fall scenarios. Theme 4 of the research will employ similar approaches, but will utilize mechanical hip impact simulators (i.e. a drop tower) to generate the experimental data used for subsequent model validation/refinement. The final phase of the proposed research (Theme 5) will utilize all experimental paradigms to investigate the ability of novel engineering devices and materials to alter impact dynamics during lateral falls on the hip. In summary, the proposed research is novel in its use of complementary research paradigms that will collectively result in a robust, and extremely well-validated, musculoskeletal model of the pelvis in response to lateral impacts. In addition, the resulting data will provide fundamental insights into the biomechanical properties of engineering-based protective devices and materials which could be integrated into the design of more effective products in future research applications.

我感兴趣的领域是与组织负荷相关的肌肉骨骼生物力学，以及高龄对这些关系的作用。在此框架内，拟议的研究计划将产生新的见解的基本机制的动态骨盆在横向影响。对于5年的地平线上提出的赠款，我的短期目标是表征系统状态参数的身体在瞬间的影响开始在横向福尔斯在臀部（主题1）。这些知识将为中期目标提供信息，即开发和验证一个可靠的数学模型，该模型可准确预测在跌倒相关冲击期间施加在骨盆上的载荷。模型开发的初始阶段将侧重于人类志愿者的低能量影响（主题2）。具体来说，200名人类参与者将在各种身体配置中经历臀部的低能量侧向福尔斯跌倒。收集的数据将包括作用力、压力分布、运动学和肌肉激活水平。此外，将使用双X线吸收测定法、超声和身体阻抗分析进行详细的骨骼几何结构和身体组成评估。由此产生的数据将用于开发一个数学模型，该模型可准确预测在髋关节侧向福尔斯跌落期间施加到外侧骨盆的时变载荷。将评估各种模型类型，包括：i）集总参数; ii）赫兹接触; iii）多元回归方法。最有希望的模型将使用参与者数据的子集进行初步验证。在主题3中，尸体（通过滑铁卢大学解剖学院获得）将用于进一步验证或改进骨盆撞击模型。除了复制人类志愿者进行的低严重性影响外，模型验证将扩展到更能代表最坏情况下坠落情景的更高能量影响。研究主题4将采用类似的方法，但将利用机械髋关节撞击模拟器（即落塔）生成用于后续模型验证/改进的实验数据。拟议研究的最后阶段（主题5）将利用所有实验范例，研究新型工程设备和材料在髋关节侧向福尔斯跌落过程中改变冲击动力学的能力。总之，所提出的研究是新颖的，在其使用的互补的研究范式，将共同导致一个强大的，非常有效的，肌肉骨骼模型的骨盆在应对横向冲击。此外，由此产生的数据将为基于工程的保护装置和材料的生物力学特性提供基本见解，这些保护装置和材料可以在未来的研究应用中集成到更有效的产品设计中。