Pathways controlling actin remodeling during cell migration

细胞迁移过程中控制肌动蛋白重塑的途径

• 批准号: RGPIN-2015-06298
• 负责人: Lee, Jonathan
• 金额: $ 2.19万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=657032
• 关键词: Pathways; controlling; actin; remodeling; during

The focus of this proposal is on understanding, at the molecular level, the mechanisms by which cells migrate from one place to another. Cells are constructed much like houses; they have an internal rigid structure like the lumber that frames a home and an external skin akin to walls and a roof. When cells move, they must alter both their external and internal structure. Scientists describe this process as remodeling. A fundamental issue in cell biology is understanding how remodeling is controlled and how it is coordinated with other cellular processes such as cell divisions.******There are three goals of this proposal. In the first we will identify the pathway by which the FLNa protein regulates cell migration. In the second we will determine how co-operation between tow proteins, FHOD1 and Vimentin, control cell migration. In the final goal, we will determine how the protein PI4KIIIß controls in which direction cells decide to.******This works hopes to understand the basic and fundamental process of cell migration. We hope to train three people in this important aspect of science. **

这项建议的重点是在分子水平上理解细胞从一个地方迁移到另一个地方的机制。 细胞的构造很像房子;它们有一个内部的刚性结构，就像房子的框架木材和一个类似于墙壁和屋顶的外部皮肤。 当细胞移动时，它们必须改变其外部和内部结构。 科学家将这一过程称为重塑。细胞生物学的一个基本问题是了解重塑是如何控制的，以及它如何与其他细胞过程（如细胞分裂）协调。这项建议有三个目标。首先，我们将确定FLNa蛋白调节细胞迁移的途径。 在第二部分中，我们将确定FHOD 1和Vimentin这两种蛋白之间的协同作用如何控制细胞迁移。 在最后的目标中，我们将确定蛋白质PI 4激酶如何控制细胞决定的方向。这项工作希望了解细胞迁移的基本和根本过程。 我们希望在科学的这一重要方面培养三个人。**