Rescue Electrical Conduction of Heart Scar Tissue to Diminish Cardiac Arrhythmia

拯救心脏疤痕组织的电传导以减少心律失常

• 批准号: 523668-2018
• 负责人: Li, RenKe
• 金额: $ 5.22万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=657495
• 关键词: Rescue; Electrical; Conduction; Heart; Scar

Heart attacks and heart failure are the main causes of disability and death around the world**and in Canada. After a heart attack, the death of muscle cells causes a scar to form in the**heart. This scar stops the normal path of electrical signals that allows the heart to beat in a**coordinated fashion to efficiently eject blood from the heart. In addition, the disrupted signals**can induce extra inefficient heart beats (arrhythmia). Patients with abnormal conduction or**arrhythmias often need a pacemaker, but electrical stimulation of the heart from the**pacemaker disrupts the normal beating sequence and induces dysfunction of the heart. Both**heart attack and the electrical stimulation result in abnormal signal conduction in the heart.**We will create new conductive biomaterials which will repair the heart and properly conduct**electrical signals across the scar following a heart attack. The new materials will enhance the**transmission of electrical signals that control the pumping of the heart. The goal is to restore**the normal pattern of coordinated heart contraction for heart diseases described above. One**biomaterial is a gel that will be injected into the scar tissue to improve the electrical signaling**propagation of the heart. The second biomaterial is a membrane which will be applied to the**surface of the damaged heart. Our new materials are unique because they will facilitate**electrical conduction and keep the heart beating synchronously. We will measure how well**the gel and the membrane conduct electrical signals and how well they coordinate the heart**beats.**Our aim is to provide a new treatment for cardiac patients that will be more effective than**current therapies. This new approach could allow patients to return to their normal lifestyle**and remain active without the need of a pacemaker. The overall impact of our proposed**research is to improve the quality of life for patients, and reduce the burden of heart disease**for both patients and the healthcare system.

心脏病发作和心力衰竭是世界各地 ** 和加拿大残疾和死亡的主要原因。心脏病发作后，肌肉细胞的死亡会在心脏上形成疤痕。这个疤痕阻止了电信号的正常路径，使心脏以一种协调的方式跳动，以有效地从心脏中排出血液。此外，中断的信号 ** 会引起额外的低效心跳（心律失常）。传导异常或心律失常的患者通常需要起搏器，但起搏器对心脏的电刺激会破坏正常的跳动顺序，导致心脏功能障碍。心脏病发作和电刺激都会导致心脏信号传导异常。我们将创造新的导电生物材料，这些材料将修复心脏并在心脏病发作后通过疤痕正确传导 ** 电信号。新材料将增强控制心脏泵血的电信号的传输。其目的是恢复上述心脏病患者心脏协调收缩的正常模式。一种生物材料是凝胶，它将被注射到疤痕组织中，以改善心脏的电信号传播。第二种生物材料是一种膜，将被应用于受损心脏的表面。我们的新材料是独一无二的，因为它们将促进电传导并保持心脏同步跳动。我们将测量凝胶和膜传导电信号的能力以及它们协调心脏跳动的能力。我们的目标是为心脏病患者提供一种新的治疗方法，这种方法比目前的治疗方法更有效。这种新方法可以让患者恢复正常的生活方式 **，并在不需要起搏器的情况下保持活跃。我们提出的研究的总体影响是提高患者的生活质量，减轻患者和医疗保健系统的心脏病负担。