Revealing the contribution of medial septal glutamatergic neurons in spatial navigation and memory using combination of calcium imaging, electrophysiological recordings and optogenetic in freely behaving mice.

通过结合钙成像、电生理记录和光遗传学，揭示自由行为小鼠的内侧间隔谷氨酸能神经元在空间导航和记忆中的贡献。

• 批准号: 397513
• 负责人: Bott Jean-Bastien
• 金额: $ 3.28万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-11-01 至 2019-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=397513&lang=en
• 关键词: Cognition; Electrophysiology; Freely Behaving Calcium Imaging; Memory; Mice; Optogenetic

Memory functions decline during aging is a major health issue. Inefficient spatial navigation and the accompanying feeling of being lost often came as among the first source of incapacitation during the early stages of Alzheimer's disease. So far, attempt

衰老过程中记忆功能下降是一个主要的健康问题。在阿尔茨海默病的早期阶段，无效的空间导航和伴随的迷失感通常是失能的第一个来源。到目前为止，