Design of Mechatronics Systems

机电一体化系统设计

• 批准号: RGPIN-2015-05189
• 负责人: Micheau, Philippe
• 金额: $ 2.48万
• 依托单位: Université de Sherbrooke
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=659753
• 关键词: Design; Mechatronics; Systems

The global context of my research program has been, and will be for the coming years, in the design of mechatronic systems, and for the next 5 years I will focus on the control of liquid ventilator.****Total liquid ventilation (TLV) consists in completely filling the lungs with a breathable perfluorocarbon liquid (PFC) and using a dedicated liquid ventilator to move the liquid into and from the lungs. The ultimate objective is to develop liquid ventilators for all ages (newborns, infants and adults) and introduce TLV in hospitals and ambulances for different therapeutic treatments. In fine, the liquid ventilator will provide an efficient lung lavage for newborns, a superior respiratory support for patients in severe acute respiratory distress, and neuroprotective effects by fast induction of hypothermia for stroke survivors.****The development of control and monitoring strategies in TLV implies a perfect understanding of fundamental fluid-structure interactions in PFC-filled lungs, since the fundamental principle of TLV is the total elimination of the air-lung interface. Such alteration of the fluid-structure interaction in PFC-filled lungs provides therapeutic advantages for patients, but also creates fundamental flow limitations in the airways (the trachea can be unstable and collapse) and the rheological behavior of PFC in the lungs is largely unknown.****The objective of student PhD1 (years 1-3) is to develop real-time monitoring strategies (e.g. alveolar pressure, respiratory mechanics, etc.) based on models of the complicated rheological behavior of PFC in the lungs. The objective of student MScA1 (years 1-2) is to model the flow limitation non-linear process in PFC-filled airways in order to compare the actual flow control strategies. The objective of PhD3 (years 3-5) is to optimize the flow control strategies for uncertain lung models (relative to adult weight, animal models or humans, with or without lung diseases, normothermia or hypothermia). All developed algorithms and control strategies will be implemented and assessed by in-vitro and in-vivo animal experiments.****The developed monitoring strategies will inform the clinician regarding lung disease evolution such as the state of the partially obstructed airways during lung lavage. The advantages/drawback of the actual and optimized control strategies will be very helpful to clinicians to ensure efficient and safe TLV.****In addition to the research insights it promises (publications related to TLV), this program will propose the development of vibration model and control methods that will impact other domains.****Since this program will be performed to support parallel pre-clinical research to prepare the first human pilot study, it will contribute in a major medical breakthrough. The impact in the medical field of this first feasibility study will be such that it will highlight the liquid ventilator.***

我的研究计划的全球背景一直是，并且将在未来几年的设计中，在接下来的5年中，我将重点关注液体呼吸机的控制。最终目标是开发所有年龄段（新生儿，婴儿和成人）的液体呼吸机，并在医院和救护车中引入TLV，以进行不同的治疗治疗。在罚款中，液体呼吸机将为新生儿提供有效的肺灌洗，对严重急性呼吸窘迫的患者提供的优质呼吸支持以及通过快速诱导中风幸存者的低温诱导来提供神经保护作用。消除气肺界面。充满PFC的肺流体结构相互作用的这种变化为患者提供了治疗优势，但也会在气道中产生基本的流动限制（气管可能是不稳定的，并且倒塌），并且PFC在肺中的流行性行为在很大程度上是未知的。呼吸力学等）基于肺中PFC的复杂流变行为的模型。学生MSCA1（1 - 2年）的目的是对PFC填充气道中的流动限制进行建模，以比较实际的流量控制策略。 PHD3（3 - 5年）的目的是优化不确定的肺模型（相对于成人体重，动物模型或人类，有或没有肺部疾病，Normothermia或Wormothermia或Prodyptermia）的流动控制策略。所有开发的算法和控制策略将由视野和体内动物实验实施和评估。实际和优化的控制策略的优势/缺点对临床医生将非常有帮助，以确保有效的tlv。****除了其承诺的研究见解之外（与TLV相关的出版物）外，该计划还将提出振动模型和控制方法的开发，这些方法将对其他域名进行研究，以便在PRALSITAL中贡献了该计划。突破。第一次可行性研究的医疗领域的影响将是这样，它将突出液态呼吸机。***