Physics of Biomaterials

生物材料物理学

• 批准号: CRC-2015-00004
• 负责人: Slepkov, Aaron
• 金额: $ 7.29万
• 依托单位: Trent University
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=665404
• 关键词: Physics; Biomaterials

Nonlinear microscopy is revolutionizing the imaging and characterization of biomaterials. The simultaneous integration of several imaging techniques is known as multimodal microscopy. We will continue the development of novel chemically-specific and label-free nonlinear optical imaging modalities that can be integrated into our custom-built ultrafast-laser-based nonlinear optical microscope, for true multimodal nonlinear-optical microscopy. Such modalities will include second-harmonic generation and two-photon fluorescence, as well as stimulated vibrational techniques such as CARS and SRS. This research will then enable rapid micro-spectroscopic characterization of structure and dynamic processes in natural and hybrid biomaterials of technological and biomedical importance to Canada.

非线性显微镜是革命性的成像和表征的生物材料。同时集成几种成像技术被称为多模态显微镜。我们将继续开发新的化学特异性和无标签非线性光学成像模式，这些模式可以集成到我们定制的基于超快激光的非线性光学显微镜中，实现真正的多模态非线性光学显微镜。这些模式将包括二次谐波产生和双光子荧光，以及受激振动技术，如CARS和SRS。这项研究将使对加拿大具有重要技术和生物医学意义的天然和混合生物材料的结构和动态过程的快速微光谱表征成为可能。