Physics of Biomaterials

非线性显微镜正在给生物材料的成像和表征带来革命性的变化。几种成像技术的同时集成被称为多模式显微镜。我们将继续开发新的化学特定和无标签的非线性光学成像模式，这些模式可以集成到我们定制的基于超快激光的非线性光学显微镜中，以实现真正的多模式非线性光学显微镜。这种模式将包括二次谐波产生和双光子荧光，以及受激发的振动技术，如CARS和SRS。这项研究将能够对对加拿大具有重要技术和生物医学意义的天然和混合生物材料的结构和动态过程进行快速显微光谱表征。

Nonlinear microscopy is revolutionizing the imaging and characterization of biomaterials. The simultaneous integration of several imaging techniques is known as multimodal microscopy. We will continue the development of novel chemically-specific and label-free nonlinear optical imaging modalities that can be integrated into our custom-built ultrafast-laser-based nonlinear optical microscope, for true multimodal nonlinear-optical microscopy. Such modalities will include second-harmonic generation and two-photon fluorescence, as well as stimulated vibrational techniques such as CARS and SRS. This research will then enable rapid micro-spectroscopic characterization of structure and dynamic processes in natural and hybrid biomaterials of technological and biomedical importance to Canada.