Porous peptide frameworks to host organic molecules and solid-state reactions

承载有机分子和固态反应的多孔肽框架

• 批准号: RGPIN-2015-04381
• 负责人: Soldatov, Dmitriy
• 金额: $ 1.46万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=665561
• 关键词: Porous; peptide; frameworks; host; organic

The proposed research will utilize peptide materials as a novel green matrix for storing organic molecules and conducting synthetic reactions in the solid state. The obtained data will form basic knowledge for future studies and applications of solid peptide-based materials. The formation of inclusion compounds and co-crystals will be determined using screening techniques. The crystal structure and stability of the new materials will be elucidated. Finally, the reactivity of molecules in the solids will be investigated in detail.******The layered supramolecular architecture of peptides and incorporation of guest molecules in the interlayer space will be exploited. It is proposed that the architecture can be used for selective inclusion, stabilization and storage of various organic species, as well as a reaction vessel for solid state reactions. The desired inclusion properties and reactivity could be achieved through a proper control by weak non-covalent interactions such as hydrogen bonds and van der Waals forces. ******The reactions will be induced either thermally or photochemically. Two model reactions will be investigated in detail: thermally induced cyclization of dipeptides and [2+2] photodimerization of unsaturated molecules residing in the peptide matrix. The incidence of the reactions, the conversion rate, yield and stereospecificity will be studied as a function of the molecular structure of the reagent, solid state structure of the crystal, and external conditions used. Better understanding of these two types will help to extend the synthetic strategies to other types of solid state reactions in these materials. Further, the reactivity of longer oligopeptides will be studied as a function of the molecular size and crystal structure they form. ******The chemical transformations of short peptide molecules in the solid state and chemical reactions that involve other molecules incorporated in the peptide solids will be studied as a potential alternative to currently used solvent-based synthetic methods. The obtained knowledge will contribute to future economic development by replacing current industrial processes with new procedures that satisfy the principles of Green Chemistry. The proposed research will also identify new uses of peptides in pharmaceutical, food and cosmetic industries through the introduction of novel peptide-based solids where the bioactive molecules are incorporated and through identification of the stability limits of these biocompatible, environmentally friendly materials.******The proposed plan implies involvement of young researchers both on graduate and undergraduate levels with a great opportunity to learn novel approaches to organic synthesis, solid state chemistry, physicochemical analysis including crystallography, thermal analysis and spectroscopic techniques.

拟议的研究将利用肽材料作为一种新型的绿色基质，用于储存有机分子并在固态下进行合成反应。所获得的数据将为未来基于固体肽的材料的研究和应用提供基础知识。将使用筛选技术确定包合化合物和共晶体的形成。将阐明新材料的晶体结构和稳定性。最后，将详细研究固体中分子的反应性。将利用肽的层状超分子结构和在层间空间中掺入客体分子。提出了该结构可用于各种有机物种的选择性包合、稳定和储存，以及用于固态反应的反应容器。通过弱的非共价相互作用如氢键和货车范德华力的适当控制，可以实现所需的包合物性质和反应性。** 反应将通过热或光化学方式诱导。两个模型反应将进行详细研究：热诱导环化的二肽和[2+2]光二聚化的不饱和分子居住在肽矩阵。将研究反应的发生率、转化率、产率和立体特异性作为试剂的分子结构、晶体的固态结构和所用外部条件的函数。更好地理解这两种类型将有助于将合成策略扩展到这些材料中的其他类型的固态反应。此外，较长的寡肽的反应性将作为它们形成的分子大小和晶体结构的函数进行研究。** 将研究短肽分子在固态下的化学转化和涉及掺入肽固体中的其他分子的化学反应，作为目前使用的基于溶剂的合成方法的潜在替代方法。所获得的知识将有助于未来的经济发展，取代目前的工业过程与新的程序，满足绿色化学的原则。拟议的研究还将确定肽在制药，食品和化妆品行业中的新用途，通过引入新的基于肽的固体，其中生物活性分子被纳入，并通过确定这些生物相容性，环境友好材料的稳定性极限。拟议的计划意味着研究生和本科生水平的年轻研究人员的参与，有很好的机会学习有机合成，固态化学，物理化学分析，包括晶体学，热分析和光谱技术的新方法。