Urgent Replacement Glovebox For Innovative Main Group Catalysis

紧急更换手套箱以实现创新的主族催化

• 批准号: RTI-2019-00004
• 负责人: Speed, Alexander
• 金额: $ 5.41万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=665696
• 关键词: Urgent; Replacement; Glovebox; Innovative; Main

We are requesting funding for a urgent replacement of our group's double glovebox. The Speed group develops catalysts and reagents for organic synthesis using principles from main group chemistry. Over the past three years, we have emerged as one of the world's leading groups in asymmetric main-group catalysis. We have shown that diazaphospholenes can be used to prepare chiral amines by catalytic reduction. Chiral amines are vital components of many biologically active molecules. We have developed catalysts that can reduce imines to amines in the presence of many other reactive functional groups, allowing access to amines that are not readily prepared using existing catalysts. We are also studying the chemical functionalization of sulfur hexafluoride, to develop mild tools to incorporate the pentafluorosulfanyl group into complex molecules at a late stage in a synthesis. While medicinal chemists anticipate that the pentafluorosulfanyl group may impart unique properties to molecules, exploration of this group has been very limited because of the absence of methods to incorporate the pentafluorosulfanyl group under mild conditions. A breakthrough in this project will open up exploration of the properties of the pentafluorosulfanyl group in a wide variety of molecules. Our work is made possible by using a glovebox to synthesize and screen air sensitive catalysts and reagents. Our current glovebox, which was a surplus item within Dalhousie's Chemistry Department when I started, has enabled our research program. Unfortunately this older model glovebox is suffering from many technical problems that have led to significant and continued downtime and the generation of false-negative results due to the repeated compromise of sensitive reagents. A modern replacement glovebox will allow the Speed group to continue exploring main group chemistry as applied to organic synthesis with the knowledge that the chemistry is being conducted in an atmosphere that is free of contaminants that will interfere with the chemistry.

我们正在申请资金紧急更换我们集团的双手套箱。Speed集团利用主族化学原理开发有机合成的催化剂和试剂。在过去的三年里，我们已经成为世界领先的不对称主基催化研究小组之一。我们已经证明，二氮磷杂环戊二烯可以用于通过催化还原制备手性胺。手性胺是许多生物活性分子的重要组成部分。我们已经开发了催化剂，可以在许多其他反应性官能团的存在下将亚胺还原为胺，从而可以获得使用现有催化剂不易制备的胺。我们还在研究六氟化硫的化学官能化，以开发温和的工具，在合成的后期阶段将五氟硫基基团并入复杂分子中。虽然药物化学家预期五氟硫基可能赋予分子独特的性质，但由于缺乏在温和条件下引入五氟硫基的方法，因此对该基团的探索非常有限。该项目的突破将开启对各种分子中五氟硫基性质的探索。我们的工作是通过使用手套箱合成和筛选空气敏感催化剂和试剂。我们目前的手套箱，这是一个多余的项目在达尔豪西的化学系当我开始，使我们的研究计划。不幸的是，这种较旧型号的手套箱存在许多技术问题，导致严重和持续的停机时间，并由于敏感试剂的反复妥协而产生假阴性结果。一个现代化的更换手套箱将允许速度组继续探索主族化学应用于有机合成的知识，化学是在一个没有污染物的气氛中进行，将干扰化学。