Urgent Replacement Glovebox For Innovative Main Group Catalysis

我们正在申请资金，紧急更换我们小组的双层手套箱。SpeedGroup使用主族化学的原理开发用于有机合成的催化剂和试剂。在过去的三年里，我们已经成为不对称主基催化领域的世界领先集团之一。结果表明，二氮磷茂化合物可用于催化还原制备手性胺类化合物。手性胺是许多生物活性分子的重要组成部分。我们已经开发出可以在许多其他活性官能团存在的情况下将亚胺还原为胺的催化剂，从而可以获得使用现有催化剂不易制备的胺。我们还在研究六氟化硫的化学官能化，以开发温和的工具，在合成的后期阶段将五氟磺酰基团结合到复杂分子中。虽然药物化学家预计五氟磺基可能赋予分子独特的性质，但由于缺乏在温和条件下结合五氟磺基的方法，对该基团的探索一直非常有限。该项目的突破将开启对各种分子中五氟磺基性质的探索。我们的工作是通过使用手套盒来合成和筛选空气敏感催化剂和试剂而实现的。我们目前的手套箱，在我开始的时候是达尔豪西化学系的剩余物品，已经使我们的研究计划得以实现。不幸的是，这个较老型号的手套盒存在许多技术问题，导致大量和持续的停机时间，并由于敏感试剂的反复妥协而产生假阴性结果。一个现代化的替换手套盒将允许Speed小组继续探索应用于有机合成的主族化学，因为知道该化学是在没有干扰化学的污染物的大气中进行的。

We are requesting funding for a urgent replacement of our group's double glovebox. The Speed group develops catalysts and reagents for organic synthesis using principles from main group chemistry. Over the past three years, we have emerged as one of the world's leading groups in asymmetric main-group catalysis. We have shown that diazaphospholenes can be used to prepare chiral amines by catalytic reduction. Chiral amines are vital components of many biologically active molecules. We have developed catalysts that can reduce imines to amines in the presence of many other reactive functional groups, allowing access to amines that are not readily prepared using existing catalysts. We are also studying the chemical functionalization of sulfur hexafluoride, to develop mild tools to incorporate the pentafluorosulfanyl group into complex molecules at a late stage in a synthesis. While medicinal chemists anticipate that the pentafluorosulfanyl group may impart unique properties to molecules, exploration of this group has been very limited because of the absence of methods to incorporate the pentafluorosulfanyl group under mild conditions. A breakthrough in this project will open up exploration of the properties of the pentafluorosulfanyl group in a wide variety of molecules. Our work is made possible by using a glovebox to synthesize and screen air sensitive catalysts and reagents. Our current glovebox, which was a surplus item within Dalhousie's Chemistry Department when I started, has enabled our research program. Unfortunately this older model glovebox is suffering from many technical problems that have led to significant and continued downtime and the generation of false-negative results due to the repeated compromise of sensitive reagents. A modern replacement glovebox will allow the Speed group to continue exploring main group chemistry as applied to organic synthesis with the knowledge that the chemistry is being conducted in an atmosphere that is free of contaminants that will interfere with the chemistry.