Urgent Replacement Glovebox For Innovative Main Group Catalysis

我们正在申请资金，以紧急更换我们集团的双手套箱。Speed小组利用主组化学的原理开发有机合成的催化剂和试剂。在过去的三年中，我们已经成为世界上不对称主基团催化的领先集团之一。我们已经证明了重氮磷烯可以通过催化还原法制备手性胺。手性胺是许多生物活性分子的重要组成部分。我们已经开发出催化剂，可以在许多其他活性官能团存在的情况下将亚胺还原为胺，从而可以获得使用现有催化剂不易制备的胺。我们也在研究六氟化硫的化学功能化，以开发温和的工具，在合成的后期将五氟磺胺基纳入复杂的分子中。虽然药物化学家预计五氟磺胺基可能赋予分子独特的性质，但由于缺乏在温和条件下结合五氟磺胺基的方法，对这一基团的探索非常有限。这个项目的突破将开启对各种分子中五氟磺胺基性质的探索。我们的工作是通过使用手套箱合成和筛选空气敏感催化剂和试剂而实现的。我们现在的手套箱，在我开始工作时是达尔豪斯化学系的剩余物品，使我们的研究项目得以开展。不幸的是，这种旧型号的手套箱存在许多技术问题，导致严重和持续的停机时间，并由于敏感试剂的反复损坏而产生假阴性结果。一个现代的替代手套箱将允许速度组继续探索主基团化学应用于有机合成，因为化学是在一个没有污染物的大气中进行的，这些污染物会干扰化学。

We are requesting funding for a urgent replacement of our group's double glovebox. The Speed group develops catalysts and reagents for organic synthesis using principles from main group chemistry. Over the past three years, we have emerged as one of the world's leading groups in asymmetric main-group catalysis. We have shown that diazaphospholenes can be used to prepare chiral amines by catalytic reduction. Chiral amines are vital components of many biologically active molecules. We have developed catalysts that can reduce imines to amines in the presence of many other reactive functional groups, allowing access to amines that are not readily prepared using existing catalysts. We are also studying the chemical functionalization of sulfur hexafluoride, to develop mild tools to incorporate the pentafluorosulfanyl group into complex molecules at a late stage in a synthesis. While medicinal chemists anticipate that the pentafluorosulfanyl group may impart unique properties to molecules, exploration of this group has been very limited because of the absence of methods to incorporate the pentafluorosulfanyl group under mild conditions. A breakthrough in this project will open up exploration of the properties of the pentafluorosulfanyl group in a wide variety of molecules. Our work is made possible by using a glovebox to synthesize and screen air sensitive catalysts and reagents. Our current glovebox, which was a surplus item within Dalhousie's Chemistry Department when I started, has enabled our research program. Unfortunately this older model glovebox is suffering from many technical problems that have led to significant and continued downtime and the generation of false-negative results due to the repeated compromise of sensitive reagents. A modern replacement glovebox will allow the Speed group to continue exploring main group chemistry as applied to organic synthesis with the knowledge that the chemistry is being conducted in an atmosphere that is free of contaminants that will interfere with the chemistry.