Canada Research Chair in Molecular Physiology

加拿大分子生理学研究主席

• 批准号: CRC-2014-00066
• 负责人: Storey, Kenneth
• 金额: $ 14.57万
• 依托单位: Carleton University
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=666053
• 关键词: Canada; Research; Chair; Molecular; Physiology

My research focuses on the biochemical mechanisms that allow animals to endure severe environmental challenges. Survival often involves entry into torpor or dormant states and our studies of hibernation, natural freeze tolerance, dehydration resistance, and survival without oxygen discover the underlying principles of stress resistance and hypometabolism across the animal kingdom. My research identifies the molecular regulatory mechanisms that suppress metabolic functions, the signaling systems that coordinate cellular responses, and the changes in gene expression that produce stabilizing, defensive or regulatory proteins that support long term life extension. The research has multiple applications for organ preservation technology in transplant medicine.

我的研究重点是使动物能够忍受严峻环境挑战的生化机制。生存通常涉及进入麻木或休眠状态，我们对冬眠，自然冷冻耐受性，脱水抗性和无氧生存的研究发现了整个动物王国的应激抗性和代谢低下的基本原则。我的研究确定了抑制代谢功能的分子调控机制，协调细胞反应的信号系统，以及产生稳定，防御或调节蛋白的基因表达的变化，这些蛋白支持长期延长寿命。这项研究在移植医学中的器官保存技术有多种应用。