Canada Research Chair In Molecular Physiology

我的研究重点是使动物能够忍受严峻环境挑战的生化机制。生存通常涉及进入麻木或休眠状态，我们对冬眠，自然耐寒性，脱水性和无氧生存的研究发现了动物王国抗应激和低代谢的基本原理。我的研究确定了抑制代谢功能的分子调节机制，协调细胞反应的信号系统，以及产生稳定、防御或调节蛋白质的基因表达变化，这些蛋白质支持长期寿命延长。该研究对器官保存技术在移植医学中的应用具有多方面的意义。

My research focuses on the biochemical mechanisms that allow animals to endure severe environmental challenges. Survival often involves entry into torpor or dormant states and our studies of hibernation, natural freeze tolerance, dehydration resistance, and survival without oxygen discover the underlying principles of stress resistance and hypometabolism across the animal kingdom. My research identifies the molecular regulatory mechanisms that suppress metabolic functions, the signaling systems that coordinate cellular responses, and the changes in gene expression that produce stabilizing, defensive or regulatory proteins that support long term life extension. The research has multiple applications for organ preservation technology in transplant medicine.