Hormonal Integration of Feeding, Metabolism, Growth and Reproduction in Fish

鱼类摄食、代谢、生长和繁殖的激素整合

• 批准号: RGPIN-2017-04956
• 负责人: Unniappan, Suraj
• 金额: $ 2.33万
• 依托单位: University of Saskatchewan
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=667381
• 关键词: Hormonal; Integration; Feeding; Metabolism; Growth

Fish is a major food source around the globe. There is a rapidly growing demand for aquaculture to meet the demand for fish used for consumption. This necessitates technologies aimed to facilitate growth, reproductive success and weight gain of cultured fishes. Sustainable aquaculture can only be improved through evidence based scientific approaches, including the type of research outlined in this application. Knowledge generated by basic research on hormones is critical in refining aquaculture practices. For example, currently there are hormone-based drugs that stimulate reproductive success, hormone-overexpressing strains of fast growing fish, and aquaculture practices that utilize diets to modulate beneficial hormones in fish. The vision, and long-term goal of my research program is to better understand how hormones regulate food intake, metabolism, growth and reproduction in fish. The eventual outcomes of this research are generation of new knowledge and betterment of aquaculture practices. In line with this overarching goal, my NSERC Discovery Grant funded research over the past decade has made seminal contributions in characterizing a large number of hormones and their roles in the regulation of feeding, growth, metabolism and reproduction. I hypothesize that feeding, metabolism, growth and reproduction are interlinked by novel hormones (eg: irisin, pheonixin) in fish. The short-term objectives of the research proposed here are to (i) characterize the role of novel hormones on metabolism, growth and reproduction, (ii) study the mechanisms these hormones use to elicit their functions, and (iii) to develop strategies to effectively utilize hormones we identified to induce growth and spawning in fish. Using zebrafish, goldfish and rainbow trout, widely used models for the type of research outlined here, I will employ a number of cutting-edge research techniques to study hormonal regulation of fish metabolism, growth and reproduction. I anticipate these novel hormones to have significant biological effects in fish. In addition, this research will validate combinations of hormones and diets as potential strategies in aquaculture for improving fish yield. The results of the research outlined here will provide (i) significant knowledge on the hormonal regulation of food intake, metabolism, growth and reproduction in fish, and (ii) is strongly expected to benefit fisheries and aquaculture in developing strategies to augment growth and reproduction of fish. This interdisciplinary research provides outstanding training opportunities for a large number of highly qualified personnel, who will join careers that require highly specific skill sets. This research will contribute to sustain Canada as a leader in aquaculture, and our country as a reservoir of talent pool for the future workforce.

鱼是全球的主要食物来源。为了满足消费用鱼的需求，对水产养殖的需求迅速增长。这就需要旨在促进养殖鱼类生长、繁殖成功和增重的技术。只有通过基于证据的科学方法，包括本申请中概述的研究类型，才能改善可持续水产养殖。激素基础研究产生的知识对于改进水产养殖做法至关重要。例如，目前有以激素为基础的药物刺激繁殖成功，激素过度表达的快速生长鱼类品种，以及利用饲料调节鱼类有益激素的水产养殖做法。我的研究项目的远景和长期目标是更好地了解激素如何调节鱼类的食物摄入、代谢、生长和繁殖。这项研究的最终成果是产生新的知识和改善水产养殖做法。为了实现这一总体目标，我在过去十年中由NSERC发现基金资助的研究在描述大量激素及其在喂养、生长、代谢和繁殖调节中的作用方面做出了开创性的贡献。我假设鱼类的摄食、新陈代谢、生长和繁殖都是由新的激素（如鸢尾素、酚素）联系在一起的。本文提出的短期研究目标是：(1)表征新激素在代谢、生长和繁殖中的作用，(2)研究这些激素引发其功能的机制，(3)制定有效利用我们发现的激素诱导鱼类生长和产卵的策略。我将使用斑马鱼、金鱼和虹鳟鱼这些在这里概述的研究类型中被广泛使用的模型，采用一些前沿的研究技术来研究鱼类代谢、生长和繁殖的激素调节。我预计这些新型激素将对鱼类产生显著的生物学效应。此外，这项研究将验证激素和饲料组合作为水产养殖中提高鱼类产量的潜在策略。这里概述的研究结果将提供(i)关于鱼类食物摄入、代谢、生长和繁殖的激素调节的重要知识，以及（ii）在制定促进鱼类生长和繁殖的战略方面有望使渔业和水产养殖业受益。这项跨学科研究为大量高素质人才提供了优秀的培训机会，他们将加入需要高度特定技能的职业。这项研究将有助于维持加拿大在水产养殖领域的领导地位，并有助于使我国成为未来劳动力的人才库。