"Hormonal Regulation and Integration of Feeding, Metabolism and Reproduction in Fish"

我的研究计划的愿景是更好地了解荷尔蒙如何调节鱼类的摄食、新陈代谢和繁殖。我过去的研究在确定鱼类中大量激素的特征方面做出了重大贡献。我研究的长期目标是发现新的荷尔蒙及其功能。我假设鱼的摄食、新陈代谢和繁殖是由新的激素(例如：Ghrelin，肽YY)相互关联的。这项研究的短期目标是(I)确定激素如何调节新陈代谢和繁殖，(Ii)研究这些激素利用什么机制来激发其功能，以及(Iii)开发有效利用激素诱导鱼类生长和产卵的策略。利用斑马鱼和金鱼这两种被广泛用于这类研究的模型，我将使用一些尖端研究技术来研究鱼类新陈代谢和繁殖的激素调节。我预计这些新奇的荷尔蒙会对鱼类产生重大的生物效应。我的研究将描述鱼类中重要的新型分子。此外，这项研究将验证激素和饲料的组合作为水产养殖中提高鱼类产量的潜在策略。这里概述的研究结果将提供(I)重要的补充信息，将增强我们对鱼类摄食、新陈代谢和繁殖的激素调节的知识，以及(Ii)将极有希望有利于渔业和水产养殖，以促进养殖鱼类的生长和繁殖。

The vision of my research program is to better understand how hormones regulate food intake, metabolism and reproduction in fish. My research in the past has made significant contributions in characterizing a large number of hormones in fish. The long-term goal of my research is to discover new hormones and their functions. I hypothesize that feeding, metabolism, and reproduction are interlinked by novel hormones (eg: ghrelin, peptide YY) in fish. The short-term objectives of the research proposed here are to (i) identify how hormones regulate metabolism and reproduction, (ii) study what mechanisms these hormones use to elicit its functions, and (iii) to develop strategies to effectively utilize hormones to induce growth and spawning in fish. Using zebrafish and goldfish, widely used models for this type of research, I will employ a number of cutting-edge research techniques to study hormonal regulation of fish metabolism and reproduction. I anticipate these novel hormones to have significant biological effects in fish. My research will characterize important novel molecules in fish. In addition, this research will validate combination of hormones and diets as potential strategies in aquaculture for improving fish yield. The results of the research outlined here will provide (i) significant additional information that will enhance our knowledge about the hormonal regulation of food intake, metabolism and reproduction in fish, and (ii) is strongly expected to benefit fisheries and aquaculture to promote growth and reproduction of cultured fish.