"Hormonal Regulation and Integration of Feeding, Metabolism and Reproduction in Fish"

我的研究项目的愿景是更好地了解激素如何调节鱼类的食物摄入、代谢和繁殖。在过去的研究中，我对鱼类体内大量激素的表征做出了重要贡献。我研究的长期目标是发现新的激素及其功能。我假设鱼类的进食、新陈代谢和繁殖是由新的激素（如生长素、肽YY）相互联系的。本文提出的短期研究目标是：(i)确定激素如何调节代谢和繁殖，（ii）研究这些激素使用什么机制来引发其功能，以及（iii）制定有效利用激素诱导鱼类生长和产卵的策略。我将使用斑马鱼和金鱼这两种被广泛用于这类研究的模型，采用一些前沿的研究技术来研究鱼类代谢和繁殖的激素调节。我预计这些新型激素将对鱼类产生显著的生物学效应。我的研究将描述鱼类中重要的新分子。此外，本研究将验证激素和饲料组合作为水产养殖中提高鱼类产量的潜在策略。这里概述的研究结果将提供(i)重要的额外信息，将增强我们对鱼类食物摄入、代谢和繁殖的激素调节的认识，以及（ii）强烈期望有利于渔业和水产养殖，以促进养殖鱼类的生长和繁殖。

The vision of my research program is to better understand how hormones regulate food intake, metabolism and reproduction in fish. My research in the past has made significant contributions in characterizing a large number of hormones in fish. The long-term goal of my research is to discover new hormones and their functions. I hypothesize that feeding, metabolism, and reproduction are interlinked by novel hormones (eg: ghrelin, peptide YY) in fish. The short-term objectives of the research proposed here are to (i) identify how hormones regulate metabolism and reproduction, (ii) study what mechanisms these hormones use to elicit its functions, and (iii) to develop strategies to effectively utilize hormones to induce growth and spawning in fish. Using zebrafish and goldfish, widely used models for this type of research, I will employ a number of cutting-edge research techniques to study hormonal regulation of fish metabolism and reproduction. I anticipate these novel hormones to have significant biological effects in fish. My research will characterize important novel molecules in fish. In addition, this research will validate combination of hormones and diets as potential strategies in aquaculture for improving fish yield. The results of the research outlined here will provide (i) significant additional information that will enhance our knowledge about the hormonal regulation of food intake, metabolism and reproduction in fish, and (ii) is strongly expected to benefit fisheries and aquaculture to promote growth and reproduction of cultured fish.