Sex steroid hormones as modulators of neurovascular function

性类固醇激素作为神经血管功能的调节剂

• 批准号: RGPIN-2018-05961
• 负责人: Usselman, Charlotte
• 金额: $ 2.11万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=667416
• 关键词: Sex; steroid; hormones; modulators; neurovascular

The cardiovascular system is a critical component of the body's adaptations to the stressors of daily life. Indeed, a wide variety of stimuli evoke acute and necessary cardiovascular responses, including talking, singing, walking, standing, exercising, and many more. Within the cardiovascular system, it is interactions between the sympathetic nervous system (the “fight or flight” system) and the resistance blood vessels which govern many of these reflex responses. However, there remains a great deal yet to be understood regarding these important regulatory mechanisms, particularly with respect to the effects of sex and sex hormones on these mechanisms. ***While it is now widely acknowledged that cardiovascular control mechanisms often differ between men and women, we still possess a poor understanding of which cardiovascular reflexes differ between the sexes (i.e. comparisons of the responses to standing versus the responses to exercising) as well as why such control mechanisms would be different between men and women. Likely candidates for the latter include the sex hormones, particularly estrogen and progesterone. The effects of estrogen on blood vessels has been well established by decades of study. However, much less is known regarding the extent to which estrogen affects the sympathetic nervous system, and even less is known regarding the sympathetic or vascular effects of progesterone. ***Therefore, the purpose of this proposal is to shed light on the sympathetic and vascular effects of estrogen and progesterone in young healthy humans. These studies will provide novel insight into the complex interactions which occur between the sympathetic nervous system and the vascular system, particularly in women. We have also designed these experiments to allow us to differentiate between the independent effects of estrogen and progesterone. Combining these methodologies with our comprehensive measures of reflex cardiovascular regulation, we aim to provide novel insight into the roles of estrogen and progesterone in governing the reflex activation of the sympathetic nervous system and the downstream consequences in the peripheral vasculature. ***The results from these studies will enhance our fundamental understanding of the human body's responses to different stressors of daily life in both men and women.

心血管系统是身体适应日常生活压力的重要组成部分。事实上，各种各样的刺激引起急性和必要的心血管反应，包括说话，唱歌，走路，站立，锻炼等等。在心血管系统中，交感神经系统（“战斗或逃跑”系统）和阻力血管之间的相互作用控制了许多反射反应。然而，关于这些重要的调节机制，特别是关于性和性激素对这些机制的影响，仍然有很多东西有待了解。* 虽然现在人们普遍认为，男性和女性的心血管控制机制往往不同，但我们仍然不太了解男女之间的心血管反射差异（即对站立的反应与对运动的反应的比较）以及为什么这种控制机制在男性和女性之间会有所不同。后者可能的候选者包括性激素，特别是雌激素和孕酮。雌激素对血管的影响已经通过几十年的研究得到了很好的证实。然而，关于雌激素影响交感神经系统的程度知之甚少，关于孕酮的交感神经或血管效应知之更少。* 因此，本提案的目的是阐明雌激素和孕激素对年轻健康人的交感神经和血管的影响。这些研究将为交感神经系统和血管系统之间发生的复杂相互作用提供新的见解，特别是在女性中。我们还设计了这些实验，使我们能够区分雌激素和孕激素的独立作用。结合这些方法与我们的反射心血管调节的综合措施，我们的目标是提供新的洞察到的作用，雌激素和孕激素在管理交感神经系统的反射激活和下游的后果在外周血管系统。*** 这些研究的结果将加强我们对男性和女性日常生活中不同压力源的人体反应的基本理解。