Personalized nutrition

个性化营养

• 批准号: 533998-2018
• 负责人: Vohl, MarieClaude
• 金额: $ 1.82万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=667858
• 关键词: Personalized; nutrition

Background and Problem. A number of genetic variants called single nucleotide polymorphisms (SNPs) have been previously reported by genome-wide association studies (GWAS) to be associated with the metabolic response to omega-3 fatty acids. However, little is known about the potential role of these SNPs as predictive biomarkers of the decrease in plasma triglyceride levels.****Objectives. To create a genetic panel allowing to the design of an innovative and improved DNA test for the metabolic response to omega-3 fatty acids. ****Relevance. To identify genetic biomarkers associated with the plasma triglyceride response to an omega-3 fatty acid supplementation that can be used by an industrial partner interested in nutrigenetic testing. The setting-up of this panel of SNPs will lead to the improvement of a DNA-based nutrigenomic test by the industrial partner partner. ************

背景和问题。全基因组关联研究 (GWAS) 此前曾报道，许多称为单核苷酸多态性 (SNP) 的遗传变异与 omega-3 脂肪酸的代谢反应有关。然而，人们对这些 SNP 作为血浆甘油三酯水平降低的预测生物标志物的潜在作用知之甚少。****目标。创建一个基因组，以便设计创新和改进的 DNA 测试，以检测对 omega-3 脂肪酸的代谢反应。 ****关联。识别与血浆甘油三酯对 omega-3 脂肪酸补充剂反应相关的遗传生物标志物，可供对营养遗传学测试感兴趣的工业合作伙伴使用。该 SNP 组的建立将导致工业合作伙伴改进基于 DNA 的营养基因组测试。 **********