Personalized nutrition

背景和问题。全基因组关联研究(GWAS)已经报道了许多称为单核苷酸多态(SNPs)的遗传变异与omega-3脂肪酸的代谢反应有关。然而，对于这些SNPs作为预测血浆甘油三酯水平降低的生物标志物的潜在作用，我们知之甚少。创建一个基因小组，允许设计一种创新和改进的DNA测试，以测试对omega-3脂肪酸的代谢反应。*相关性。识别与血浆甘油三酯对omega-3脂肪酸补充剂的反应相关的遗传生物标记物，可供对营养遗传学测试感兴趣的工业合作伙伴使用。这一SNPs小组的建立将导致工业伙伴改进基于DNA的营养基因组测试。************

Background and Problem. A number of genetic variants called single nucleotide polymorphisms (SNPs) have been previously reported by genome-wide association studies (GWAS) to be associated with the metabolic response to omega-3 fatty acids. However, little is known about the potential role of these SNPs as predictive biomarkers of the decrease in plasma triglyceride levels.****Objectives. To create a genetic panel allowing to the design of an innovative and improved DNA test for the metabolic response to omega-3 fatty acids. ****Relevance. To identify genetic biomarkers associated with the plasma triglyceride response to an omega-3 fatty acid supplementation that can be used by an industrial partner interested in nutrigenetic testing. The setting-up of this panel of SNPs will lead to the improvement of a DNA-based nutrigenomic test by the industrial partner partner. ************