A wearable, textile-based platform for the rapid detection of bacteria in urine.

一种基于纺织品的可穿戴平台，用于快速检测尿液中的细菌。

• 批准号: 533853-2018
• 负责人: Wheeler, Aaron
• 金额: $ 1.82万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=668446
• 关键词: wearable; textile; based; platform; rapid

Wearable devices (such as the FitbitTM) help monitor a persons vital statistics in real time. Taken a step further,**such devices may be used to monitor infections, wound-healing, or the bodys response to a pharmaceutical drug**[1]. In this project, we will develop a wearable, textile-based sensor to monitor bacterial sepsis, primarily for the**diagnosis of urinary tract infections in geriatric patients. Urinary tract infections are often diagnosed**symptomatically, and treated with broad spectrum drugs, which can lead to the development of antibiotic**resistance and chronic infection [2,3]. In the elderly, this can result in chronic or life-threatening conditions [3]**and a subsequent decline in the patients' quality of life. The device we propose to develop, will be made entirely**from textile-based materials, and will fit conveniently into the patients clothing. The analysis from the device will**help identify a bacterial pathogen in a metered amount of the patient's urine via an innovative filtration and**immunoassay-mediated approach. We thereby hope to preempt the onset of infection, and potentially aid in**determining an appropriate course of treatment.**1. Bandodkar, A. J. & Wang, J. Non-invasive wearable electrochemical sensors: A review. Trends Biotechnol. 32,**363371 (2014).**2. Rowe, T. A. & Juthani-Mehta, M. Diagnosis and Management of Urinary Tract Infection in Older Adults. Infect.**Dis. Clin. North Am. 28, 7589 (2014).**3. Kline, K. A. & Bowdish, D. M. E. ScienceDirect Infection in an aging population. Curr. Opin. Microbiol. 29,**6367 (2016).

可穿戴设备（如FitbitTM）有助于真实的时间监测一个人的生命统计数据。更进一步，** 此类设备可用于监测感染、伤口愈合或身体对药物的反应 **[1]。在这个项目中，我们将开发一种可穿戴的，基于纺织品的传感器来监测细菌性败血症，主要用于老年患者尿路感染的诊断。泌尿道感染通常是经外科诊断的，并使用广谱药物治疗，这可能导致抗生素耐药性和慢性感染的发展[2，3]。在老年人中，这可能导致慢性或危及生命的疾病[3]**，并导致患者生活质量的下降。我们建议开发的设备将完全由纺织材料制成，并将方便地放入患者的衣服中。通过创新的过滤和免疫测定介导的方法，该设备的分析将有助于确定定量患者尿液中的细菌病原体。因此，我们希望能够预先预防感染的发生，并可能有助于确定适当的治疗过程。1. Bandodkar，A. J.& Wang，J.非侵入式可穿戴电化学传感器：综述。trends Biotechnol. 32，** 363371（2014）. ** 2. Rowe，T. a. & Juthani-Mehta，M.老年人尿路感染的诊断和治疗。感染。**北美地区临床分布28，7589（2014）。3. Kline，K. a. & Bowdish，D. M. e.老年人群中的科学直接感染。Curr. opin. Microbiol. 29，** 6367（2016）。