Microfluidics For Integrated Bioanalysis

用于集成生物分析的微流控

• 批准号: CRC-2016-00001
• 负责人: Wheeler, Aaron
• 金额: $ 14.57万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=729688
• 关键词: Microfluidics; Integrated; Bioanalysis

Most of what we know about cell biology comes from ¿average¿ measurements of the biochemistries of millions of cells. This type of measurement masks information about heterogeneity, leaving significant gaps in our understanding of cell biology. Here, the applicant proposes to develop new microfluidic tools to address this challenge, with application to long-standing problems including the identification of fetal cells for prenatal screening for abnormal pregnancies, and the evaluation of how neural precursor cells contribute to recovery from stroke or other brain trauma. If successful, the tool proposed here could transform the way cell-biology questions are asked and answered.

我们对细胞生物学的大部分了解来自于对数百万个细胞的生物化学的平均测量。这种类型的测量掩盖了关于异质性的信息，在我们对细胞生物学的理解中留下了重大空白。在这里，申请人提出开发新的微流体工具来解决这一挑战，并应用于长期存在的问题，包括识别胎儿细胞用于产前筛查异常妊娠，以及评估神经前体细胞如何有助于从中风或其他脑创伤中恢复。如果成功的话，这里提出的工具可以改变细胞生物学问题的提问和回答方式。