Tuning lidocaine delivery from latex elastrator rings

调整乳胶弹性环的利多卡因输送

• 批准号: 531133-2018
• 负责人: Wulff, Jeremy
• 金额: $ 1.82万
• 依托单位: University of Victoria
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=669008
• 关键词: Tuning; lidocaine; delivery; latex; elastrator

New strategies are required to control pain in cattle undergoing castration, in order to keep abreast of mankind's**changing relationships with animals.**A common method to effect castration of young bulls is to attach a small elastic band (called an elastrator ring)**around the animal's scrotum. This cuts off blood supply, which eventually leads to the loss of the testicles. As**with other methods of castration however, application of elastrator rings necessarily causes some pain and**discomfort to the animal. In anticipation of the changing regulatory landscape - which will soon mandate that**pain mitigation strategies be employed during castration - Chinook Contract Research (CCR) is developing a**version of elastrator rings that come pre-loaded with the anesthetic lidocaine. This drug is already approved for**use in food-producing animals, and has a fast onset time that will provide effective pain relief during the**castration procedure.**The current Engage partnership with the Wulff research group at the University of Victoria will result in the**optimization of the drug-loading procedure, better analytical methods to detect drug release, and a**mock-animal method to assess delivery to tissue. These advances will allow CCR to meet upcoming patent**deadlines and play an increasing role in the $33 billion Canadian cattle sector.

需要新的策略来控制阉割牛的疼痛，以跟上人类与动物关系的变化。阉割小公牛的一种常用方法是在动物的阴囊周围系上一条小的弹性带（称为弹性环）。这会切断血液供应，最终导致睾丸的丧失。然而，与其他阉割方法一样，使用弹力环必然会给动物带来一些疼痛和不适。在不断变化的监管环境的预期-这将很快要求 ** 疼痛缓解策略在阉割期间使用-奇努克合同研究（CCR）正在开发一个 ** 版本的弹性环，预装麻醉剂利多卡因。这种药物已经被批准用于食品生产动物，并且具有快速的起效时间，可以在阉割过程中有效缓解疼痛。目前与维多利亚大学Wulff研究小组的Engage合作伙伴关系将导致药物装载程序的 ** 优化，检测药物释放的更好的分析方法，以及评估组织递送的模拟动物方法。这些进展将使CCR能够满足即将到来的专利 ** 期限，并在价值330亿美元的加拿大养牛业中发挥越来越大的作用。