Bioactive Small Molecule Synthesis

生物活性小分子合成

• 批准号: CRC-2016-00290
• 负责人: Wulff, Jeremy
• 金额: $ 5.46万
• 依托单位: University of Victoria
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=729940
• 关键词: Bioactive; Small; Molecule; Synthesis

New opportunities in personalized medicine have created a need for larger numbers of selective drug molecules. To address this need, Dr. Wulff has worked to invent efficient synthetic methods that can be used to access a suite of conformationally constrained scaffold molecules. In the second term of his CRC, he proposes to apply these scaffolds to create new drug candidates that potently and selectively bind to medicinally important protein targets. These new agents will ultimately be used for the treatment of several types of human cancer.

个性化医疗的新机遇产生了对大量选择性药物分子的需求。为了满足这一需求，Wulff 博士致力于发明有效的合成方法，可用于获得一套构象受限的支架分子。在 CRC 的第二个任期内，他建议应用这些支架来创造新的候选药物，这些候选药物可以有效地、选择性地与医学上重要的蛋白质靶标结合。这些新药最终将用于治疗几种类型的人类癌症。