Regulation and Function of Hypertranscription during Mammalian Development

哺乳动物发育过程中超转录的调节和功能

• 批准号: 402238
• 负责人: Ramalho-Santos Miguel
• 金额: $ 78.3万
• 依托单位: Sinai Health System (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-03-01 至 2024-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=402238&lang=en
• 关键词: Chromatin; Developmental Biology; Embryology; Epigenetics; Mouse; Stem Cells; Transcription

The progressive formation of an embryo is promoted by changes in the activity of genes. However, genes are not merely turned "ON" or "OFF": they can be tuned up or down, and their levels matter. Recent work from our lab and others has revealed that major

胚胎的逐渐形成是由基因活性的变化所促进的。然而，基因不仅仅是“开”或“关”：它们可以调高或调低，它们的水平很重要。我们实验室和其他实验室最近的研究表明