Expanding Excellence in Developmental Biology in Oklahoma
扩大俄克拉荷马州发育生物学的卓越水平
基本信息
- 批准号:10629614
- 负责人:
- 金额:$ 127.88万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-07-01 至 2028-06-30
- 项目状态:未结题
- 来源:
- 关键词:AddressAdvisory CommitteesAgeAppointmentAreaBioinformaticsBiomedical ResearchCaenorhabditis elegansCardiovascular systemCell Culture TechniquesCell modelCenters of Research ExcellenceCommunitiesCore FacilityDevelopmentDevelopmental BiologyDiseaseDoctor of PhilosophyDropoutDrosophila genusEnvironmentEpigenetic ProcessFacultyFertilizationFundingFutureGenomeGenomic approachGoalsHematopoietic stem cellsHereditary DiseaseHumanImageImmune systemInfrastructureInstitutionInterdisciplinary StudyInternationalJournalsLaboratoriesMentorsMolecularMusMutationOklahomaPathway interactionsPhasePhysiological ProcessesPilot ProjectsPlanariansPositioning AttributeProductivityPublishingRegenerative MedicineResearchResearch PersonnelResearch SupportResourcesScientistSenior ScientistServicesSystemSystems DevelopmentTimeTrainingUnited States National Institutes of HealthUniversitiesWomanWorkZebrafishcareercompetitive environmentfunctional genomicshuman diseasehuman modelmembermenmodel organismnovel therapeutic interventionoperationprogramstrend
项目摘要
ABSTRACT OVERALL
Developmental Biology research is fundamental to progress in determining the molecular basis of many
diseases, as well as for the rapidly emerging field of regenerative medicine. During COBRE Phases I and II,
we welcomed 12 new investigators, many of whom use model organisms (planarians, Drosophila, zebrafish,
and C. elegans) whose genomes can be efficiently manipulated to understand fundamental physiological
processes that are conserved among species. In some cases, functional genomic approaches were used to
model human mutations to understand the basis of devastating inherited diseases. All our Project Leads were
rigorously trained in Developmental Biology, published in top tier journals, and showed exceptional promise.
Their appointments were deliberately divided among four of OMRF’s Research Programs (equivalent to
academic departments) to encourage cross-fertilization and attract established investigators to the field. We
now have a critical mass of Developmental Biologists that includes COBRE-supported investigators as well as
more established faculty.
During Phases I and II we also established and expanded Cores that provide essential services to
Developmental Biologists: an Imaging Core and a Bioinformatics and Pathways Core. Our goals in Phase III
are to consolidate the progress we have made in Phases I and II by welcoming new Developmental Biologists
into our community through the support of Pilot Projects and to expand the services offered by our Cores, while
at the same time positioning them for sustainability when COBRE funding ends. We will accomplish our goals
through the following Specific Aims.
Aim 1. To expand the breadth of our research program in Developmental Biology through the choice of Pilot
Project Investigators with outstanding potential to become leaders in their fields. Aim 2. To mentor the Pilot
Project Investigators using a combination of senior scientists and recently graduated COBRE Project Leads
within existing OMRF and University of Oklahoma faculty. Aim 3. To form an External Advisory Committee of
internationally recognized Developmental Biologists to evaluate the progress of, and offer advice to, the Pilot
Project Investigators and Core Directors. Aim 4. To expand the capabilities of the Core facilities so they are
well-positioned to support the research of both current and future Developmental Biologists (including current
Pilot Project Investigators) and lay the groundwork for sustainable operation after COBRE funding ends. Aim
5. To promote scientific interactions among the Pilot Project Investigators and former Project Leads to create
an environment conducive to investigator retention.
摘要概述
发育生物学研究对于确定许多疾病的分子基础至关重要
疾病,以及快速发展的再生医学领域。在COBRE第一阶段和第二阶段,
我们迎来了12名新的研究人员,他们中的许多人使用模式生物(真涡虫,果蝇,斑马鱼,
和C. elegans),其基因组可以有效地操纵,以了解基本的生理
物种间保守的过程。在某些情况下,功能基因组学方法被用于
模拟人类突变,以了解毁灭性遗传疾病的基础。我们所有的项目负责人
在发育生物学方面受过严格的训练,在顶级期刊上发表文章,并表现出非凡的前景。
他们的任命被故意分配给OMRF的四个研究项目(相当于
学术部门),以鼓励交叉施肥和吸引既定的调查人员到外地。我们
现在有一批发展生物学家,其中包括COBRE-supported调查人员,以及
更成熟的教师队伍。
在第一阶段和第二阶段,我们还建立和扩大了核心,为以下方面提供基本服务:
发育生物学家:成像核心和生物信息学和途径核心。我们在第三阶段的目标
我们将通过欢迎新的发育生物学家来巩固我们在第一阶段和第二阶段取得的进展
通过试点项目的支持进入我们的社区,并扩大我们的核心提供的服务,同时
同时在COBRE资金结束时为他们提供可持续性。我们会实现我们的目标
通过以下具体目标。
目标1.通过选择试点项目,扩大我们在发育生物学方面的研究计划的广度
具有成为各自领域领导者的杰出潜力的项目调查员。目标二。指导飞行员
项目调查人员使用资深科学家和最近毕业的COBRE项目负责人的组合
在现有的OMRF和俄克拉荷马州大学的教师。目标3。成立对外咨询委员会,
国际公认的发育生物学家,以评估进展,并提供建议,试点
项目调查员和核心主管。目标4。扩大核心设施的能力,
有能力支持当前和未来发育生物学家的研究(包括当前的
试点项目调查员),并为COBRE资助结束后的可持续运作奠定基础。目的
5.促进试点项目研究者和前项目负责人之间的科学互动,
有利于留住调查员的环境。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Linda F Thompson其他文献
160 FUNCTIONAL CHARACTERIZATION OF ECTO-5′-NUCLEOTIDASE (ECTO-5′-NT) POSITIVE AND NEGATIVE HUMAN LYMPHOCYTES
160 外切 5′-核苷酸酶(外切 5′-NT)阳性和阴性人淋巴细胞的功能表征
- DOI:
10.1203/00006450-198807000-00184 - 发表时间:
1988-07-01 - 期刊:
- 影响因子:3.100
- 作者:
Linda F Thompson;Julie M Ruedi - 通讯作者:
Julie M Ruedi
ECTO-5′-NUCLEOTIDASE (ECTO-5′-NT) CAN USE IMP TO PROVIDE THE TOTAL PURINE REQUIREMENTS OF MITOGEN-STIMULATED HUMAN T CELLS AND HUMAN B LYMPHOBLASTS: 209
外切核苷酸酶 5′(ECTO-5′-NT)可利用 IMP 为有丝分裂原刺激的人 T 细胞和人 B 淋巴母细胞提供全部嘌呤需求:209
- DOI:
10.1203/00006450-198507000-00229 - 发表时间:
1985-07-01 - 期刊:
- 影响因子:3.100
- 作者:
Linda F Thompson - 通讯作者:
Linda F Thompson
AN EXPLANATION FOR THE HETEROGENEITY IN B LYMPHOCYTE ECTO-5′-NUCLEOTIDASE (ECT0–5′-NT) ACTIVITY IN PATIENTS WITH HYPOGAMMAGLOBULINEMIA: 208
低丙种球蛋白血症患者 B 淋巴细胞外切核酸酶(ECT0–5′-NT)活性异质性的解释:208
- DOI:
10.1203/00006450-198507000-00228 - 发表时间:
1985-07-01 - 期刊:
- 影响因子:3.100
- 作者:
Linda F Thompson;Richard P O'connor;Julie M Ruedi;John F Bastian - 通讯作者:
John F Bastian
Linda F Thompson的其他文献
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{{ truncateString('Linda F Thompson', 18)}}的其他基金
Expanding Excellence in Developmental Biology in Oklahoma
扩大俄克拉荷马州发育生物学的卓越水平
- 批准号:
9234544 - 财政年份:2013
- 资助金额:
$ 127.88万 - 项目类别:
Expanding Excellence in Developmental Biology in Oklahoma Supplement: 3D Human Lung Tissue Model to Dissect Cellular Responses upon SARS-CoV-2 Infection
俄克拉荷马州增补中扩大发育生物学的卓越性:3D 人体肺组织模型剖析 SARS-CoV-2 感染后的细胞反应
- 批准号:
10853526 - 财政年份:2013
- 资助金额:
$ 127.88万 - 项目类别:
Expanding Excellence in Developmental Biology in Oklahoma
扩大俄克拉荷马州发育生物学的卓越水平
- 批准号:
8432235 - 财政年份:2013
- 资助金额:
$ 127.88万 - 项目类别:
Expanding Excellence in Developmental Biology in Oklahoma
扩大俄克拉荷马州发育生物学的卓越水平
- 批准号:
10225569 - 财政年份:2013
- 资助金额:
$ 127.88万 - 项目类别:
Expanding Excellence in Developmental Biology in Oklahoma
扩大俄克拉荷马州发育生物学的卓越水平
- 批准号:
8625776 - 财政年份:2013
- 资助金额:
$ 127.88万 - 项目类别:
Expanding Excellence in Developmental Biology in Oklahoma
扩大俄克拉荷马州发育生物学的卓越水平
- 批准号:
10474288 - 财政年份:2013
- 资助金额:
$ 127.88万 - 项目类别:
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