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Integrin Alpha8 is a novel mediator of T lymphocyte migration across the CNS barriers

Integrin Alpha8 is a novel mediator of T lymphocyte migration across the CNS barriers
整合素 Alpha8 是 T 淋巴细胞跨中枢神经系统屏障迁移的新型介质
批准号：
401356
负责人：
Prat Alexandre
金额：
$57.12万
依托单位：
Centre hospitalier de l'Universit de Montral (CHUM)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2019
资助国家：
加拿大
项目状态：
已结题
起止时间：
2019-03-01 至 2024-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=401356&lang=en
关键词：
Autoimmunity Blood-Brain Barrier Cell Adhesion Molecules Central Nervous System Diapedesis Experimental Autoimmune Encephalomyelitis Integrins Multiple Sclerosis Neuroimmunology T Lymphocytes

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英文摘要
Multiple sclerosis (MS) is a debilitating autoimmune disease of the central nervous system (CNS) with high prevalence in young adults. The clinical symptoms of MS are the result of self-targeting immune cells migrating across the brain and spinal cord blo
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Canada Research Chair - Tier 1
  • 批准号：
    471059
  • 项目类别：
  • 资助金额：
    $101.99万
  • 财政年份：
    2022
  • 负责人：
    Prat Alexandre
  • 依托单位：
    Universit de Montral
A transgenic mouse model of multiple sclerosis offers new ways to identify mechanisms of progression and novel therapies
Integrin alpha8 is a novel mediator of pro-inflammatory T lymphocyte migration across the CNS barriers
The novel TH17-associated cytokine IL-26 mediates BBB breakdown and neuroinflammation
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