Transcription factor interplay as a driving force in the hepatic response to fasting and its dysregulation in metabolic disease

转录因子相互作用作为肝脏对禁食反应及其代谢疾病失调的驱动力

• 批准号: 400664
• 负责人: Cummins Carolyn L
• 金额: --
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-02-01 至 2022-02-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=400664&lang=en
• 关键词: Atac-Seq; Chip-Seq; Chromatin; Diabetes; Fasting; Liver; Metabolism; Nuclear Receptor; Rna-Seq; Transcription Factor

Metabolic diseases, including diabetes, obesity and non-alcoholic fatty liver disease are reaching epidemic levels worldwide. Improper cellular energy production, storage and utilization underlie many of these conditions. The enzymes that control glucose,

包括糖尿病、肥胖症和非酒精性脂肪性肝病在内的代谢性疾病正在全球范围内达到流行水平。不适当的细胞能量生产、储存和利用是许多这些情况的基础。控制葡萄糖的酶，