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Defining the role for ATF3 in recurrent pancreatic injury and PDAC

Defining the role for ATF3 in recurrent pancreatic injury and PDAC
定义 ATF3 在复发性胰腺损伤和 PDAC 中的作用
批准号：
401224
负责人：
Pin Christopher L
金额：
$55.45万
依托单位：
University of Western Ontario
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2019
资助国家：
加拿大
项目状态：
已结题
起止时间：
2019-03-01 至 2024-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=401224&lang=en
关键词：
Cre Recombinase Epigenetic Remodelling Genetically Modified Mice Histone Deacetylases Pancreatic Ductal Adenocarcinoma Pancreatitis Transcription Factors Unfolded Protein Response/Er Stress

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Pancreatic cancer is the 3rd leading cause of cancer related deaths with a 5 year survival rate of ~9% five years after diagnosis. This is due to patients not presenting with symptoms of pancreatic cancer until advanced stages of the disease. The majority
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