RNA-DIRECTED EPIGENETIC REMODELLING IN CANCER

表观遗传学描述了如何在不改变DNA序列的情况下关闭或打开基因。表观遗传学在癌症发展中起着重要作用。在这项提案中，我们正在研究一种新的假设，即在癌症中，一种类似于使用非编码RNA进行印记的机制被触发，这促进了基因簇的抑制。这一提议的结果将对我们理解癌症中的基因调控产生重大影响，并对癌症治疗具有重要的治疗价值。

Epigenetics describes how genes can be turned off or on without changing the DNA sequence. Epigenetics plays a major role in cancer development. In this proposal we are investigating a novel hypothesis that in cancer a similar mechanism to imprinting USING NON-CODING RNA is triggered and this promotes the suppression of clusters of genes. The results from this proposal will have major implications to our understanding of gene regulation in cancer and will have important therapeutic value for cancer treatment.