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Using the zebrafish as a model for chemoprevention for TP53 mutation carriers

Using the zebrafish as a model for chemoprevention for TP53 mutation carriers
使用斑马鱼作为TP53突变携带者化学预防的模型
批准号:
401265
负责人:
Berman Jason N
金额:
$61.58万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2019
资助国家:
加拿大
项目状态:
已结题
起止时间:
2019-03-01 至 2024-03-01

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中文摘要
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英文摘要
Patients with Li Fraumeni syndrome (LFS) have a mutation in a gene called TP53 in every cell in their bodies, which puts them at much greater risk for developing cancers early in life and throughout their lifetime. While surveillance programs that include
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Identifying novel strategies for leukemia prevention using zebrafish models of dnajc21-mutant Shwachman Diamond syndrome
New insights into mast cell development and contribution to malignant progression - further exploitation of the zebrafish model
  • 批准号:
    267385
  • 项目类别:
    Operating Grants
  • 资助金额:
    $41.19万
  • 财政年份:
    2012
  • 负责人:
    Berman Jason N
  • 依托单位:
Molecular interrogation and a small molecule screen of NUP98-HOXA9 induced AML in the zebrafish
  • 批准号:
    234355
  • 项目类别:
    Operating Grants
  • 资助金额:
    $12.27万
  • 财政年份:
    2011
  • 负责人:
    Berman Jason N
  • 依托单位:
Zebrafish as an in vivo model of vertebrate mast cell development and systemic mastocytosis
  • 批准号:
    190964
  • 项目类别:
    Operating Grants
  • 资助金额:
    $21.5万
  • 财政年份:
    2009
  • 负责人:
    Berman Jason N
  • 依托单位:
海外基金