Market Assessment for Universal Nanofluidic Cell with Loading Station

带装载站的通用纳米流体单元的市场评估

基本信息

批准号：
544460-2019
负责人：
Sciaini, Germán
金额：
$ 1.09万
依托单位：
University of Waterloo
依托单位国家：
加拿大
项目类别：
Idea to Innovation
财政年份：
2019
资助国家：
加拿大
起止时间：
2019-01-01 至 2020-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=675471
关键词：
Market Assessment Universal Nanofluidic Cell

项目摘要

Commercially available Nanofluidic Chip (NFC) systems are basically two Silicon wafer based nanofabricated chips with transparent windows separated by a thin spacer (typically in the order of a few hundreds of nm). In such a NFC system, even a tiny droplet of 0.1 uL suffices for the liquid to run over the top of the spacer. This increases the effective electron beam path in a non-reproducible manner. The main problem with current NFC systems is the inability to accurately and precisely control of the final liquid layer thickness and the positioning of the liquid sample (droplet).Our innovative new universal NFC and loading station system avoid this problem entirely by providing a reservoir area (or overflow catch basin) to capture the excess fluid and drain it away from the spacer thereby leaving the viewing area unaffected.University of Waterloo (UW) NFCs allow for the excess of liquid to spill over into an adjacent reservoir, without reaching the spacer area. In addition, the special shape of the chips enables the liquid droplet to self-position in the viewing area and pre-concentrate at desired level before sealing. Our NFCs are to be loaded in a specially designed loading station for minimal to none window bulging to enable control of the effective electron beam path or liquid layer thickness, and therefore better resolution images of drop-casted specimens over large viewing areas. Moreover, UW NFCs are fabricated to fit in most commonly used sample holders.

市售的纳米流体芯片（NFC）系统基本上是两个基于硅晶片的纳米制动芯片，其透明窗户被透明的垫片分开（通常按几百个NM的顺序）。在这样的NFC系统中，即使是一小滴0.1 UL的小滴足以使液体在垫片的顶部上运行。这以不可再生的方式增加了有效的电子束路径。当前NFC系统的主要问题是无法准确，准确地控制最终的液体层厚度和液体样品的位置（液滴）。我们的创新新的通用NFC和加载站系统完全避免了这个问题，通过提供储层区域（或溢出的盆地）来捕获多余的液体并将其置于空间区域，以使其远离空间区域。允许过量的液体溢出到相邻的储层中，而无需到达间隔区域。此外，芯片的特殊形状可以使液滴在观察区域中自定位，并在密封之前先在所需水平上进行浓缩。我们的NFC将被加载到一个专门设计的加载站中，以使其最小化至无窗口膨胀，以控制有效的电子束路径或液体层厚度，因此可以更好地分辨出在大型观看区域上滴入掉落标本的图像。此外，UW NFC被制造成适合最常用的样品持有人。