Rhythmic and arrhythmic brain activity: from advanced signal processing tools to new electromagnetic neuroimaging methods
节律和心律失常的大脑活动:从先进的信号处理工具到新的电磁神经成像方法
基本信息
- 批准号:RGPIN-2017-05960
- 负责人:
- 金额:$ 1.75万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2019
- 资助国家:加拿大
- 起止时间:2019-01-01 至 2020-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The main objective of this research program is to provide neuroscientists and neuro-clinicians with a new generation of signal processing and imaging tools based on the electromagnetic signals produced by the brain. Direct measurement of the electrical activity produced by the brain provides time-resolved signals which reflect the brain in action', i.e. the synchronization of neural populations, either during cognitive tasks or resting state. Sleep is also a particularly important period during which the brain generates and processes information, and undergoes plastic reorganization of the interconnected synaptic networking in order to be more efficient during the forthcoming awake time. As a matter of fact, the characterization of spontaneous brain activity during resting states or sleep in humans is among the most challenging scientific issues. Electromagnetic (EM) signals produced by the brain can be non invasively measured in two complementary ways: the usual EEG signals (Electroencephalography, i.e. electric potential measured on the scalp) and more recent MEG recordings (Magnetoencephalography, i.e. magnetic field measured around the head). As for most of electrophysiological signals, EM recordings are a complex mix of short lasting and narrow-banded oscillations (rhythmic activity), with more long-range and broadband dynamical processes without characteristic time scale (arrhythmic activity). Usual spectral analysis mostly focus on the rhythmic component, i.e. the oscillations that are usually categorized into frequency bands (delta:0.1-4 Hz; theta:4-8 Hz; alpha:8-16 Hz; beta:16-32 Hz; gamma: >32 Hz). Although the arrhythmic component has been generally modeled by power-law processes and self-similar processes without functional interpretation with respect to the brain activity, recent works has demonstrated the functional relevance of this spontaneous arrythmic signal that reflects neural activity and non linear interactions between neural populations with implication in cognition. However, this model that relies on a unique spectral exponent, cannot account for the full complexity of the real data. Based on the recent development in multifractal analysis, the main objective aims at validating new advanced signal analyses methods and numerical tools that offer new and robust spectral descriptors elucidating the coupling between rhythmic and arrhythmic components of EM neuro-physiological signals, and to localize in the brain specific neural processes associated to those components. The specific (but not restricted) field of application will be a quantitative assessment of the sleep quality and integrity based on dynamical neuro-processing tools in the healthy and aging population.
这项研究计划的主要目的是为神经科学家和神经临床医生提供基于大脑产生的电磁信号的新一代信号处理和成像工具。对大脑产生的电活动的直接测量提供了反映大脑活动的时间分辨信号,即在认知任务或休息状态下神经群的同步。睡眠也是大脑产生和处理信息的一个特别重要的时期,并且为了在即将到来的清醒时间更有效地进行相互连接的突触网络的塑性重组。事实上,描述人类在静息状态或睡眠状态下的自发大脑活动是最具挑战性的科学问题之一。大脑产生的电磁(EM)信号可以通过两种互补的方式进行无创测量:通常的EEG信号(脑电图,即在头皮上测量的电位)和最近的MEG记录(脑电图,即在头部周围测量的磁场)。对于大多数电生理信号来说,EM记录是一个复杂的短时间和窄频带振荡(节律性活动)的混合,具有更多的无特征时间尺度的远程和宽带动态过程(非节律性活动)。通常的频谱分析主要集中在节奏成分上,即通常分为频带的振荡(delta:0.1-4 Hz; theta:4-8 Hz; alpha:8-16 Hz; beta:16-32 Hz; gamma: > 32hz)。尽管心律失常成分通常是通过幂律过程和自相似过程来建模的,没有对大脑活动的功能解释,但最近的研究表明,这种自发心律失常信号的功能相关性反映了神经活动和神经群体之间的非线性相互作用,与认知有关。然而,这种模型依赖于一个独特的光谱指数,不能解释真实数据的全部复杂性。基于多重分形分析的最新发展,主要目的是验证新的先进信号分析方法和数值工具,这些方法和数值工具提供新的鲁棒谱描述符,阐明EM神经生理信号的节律和非节律成分之间的耦合,并定位与这些成分相关的大脑特定神经过程。具体(但不限于)应用领域将是基于动态神经处理工具对健康和老龄化人群睡眠质量和完整性的定量评估。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Lina, JeanMarc其他文献
Lina, JeanMarc的其他文献
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{{ truncateString('Lina, JeanMarc', 18)}}的其他基金
QuantSLEEP: A numerical toolbox for a graph signal processing of the rhythmic and arrhythmic components of sleep EEG recordings.
QuantSLEEP:一个数字工具箱,用于对睡眠脑电图记录的节律和心律失常成分进行图形信号处理。
- 批准号:
RGPIN-2022-05351 - 财政年份:2022
- 资助金额:
$ 1.75万 - 项目类别:
Discovery Grants Program - Individual
Rhythmic and arrhythmic brain activity: from advanced signal processing tools to new electromagnetic neuroimaging methods
节律和心律失常的大脑活动:从先进的信号处理工具到新的电磁神经成像方法
- 批准号:
RGPIN-2017-05960 - 财政年份:2021
- 资助金额:
$ 1.75万 - 项目类别:
Discovery Grants Program - Individual
Rhythmic and arrhythmic brain activity: from advanced signal processing tools to new electromagnetic neuroimaging methods
节律和心律失常的大脑活动:从先进的信号处理工具到新的电磁神经成像方法
- 批准号:
RGPIN-2017-05960 - 财政年份:2020
- 资助金额:
$ 1.75万 - 项目类别:
Discovery Grants Program - Individual
Rhythmic and arrhythmic brain activity: from advanced signal processing tools to new electromagnetic neuroimaging methods
节律和心律失常的大脑活动:从先进的信号处理工具到新的电磁神经成像方法
- 批准号:
RGPIN-2017-05960 - 财政年份:2018
- 资助金额:
$ 1.75万 - 项目类别:
Discovery Grants Program - Individual
Rhythmic and arrhythmic brain activity: from advanced signal processing tools to new electromagnetic neuroimaging methods
节律和心律失常的大脑活动:从先进的信号处理工具到新的电磁神经成像方法
- 批准号:
RGPIN-2017-05960 - 财政年份:2017
- 资助金额:
$ 1.75万 - 项目类别:
Discovery Grants Program - Individual
Multiscale and wavelet based signal processing for electrophysiological and optical brain imaging
用于电生理学和光学脑成像的多尺度和基于小波的信号处理
- 批准号:
238902-2012 - 财政年份:2014
- 资助金额:
$ 1.75万 - 项目类别:
Discovery Grants Program - Individual
Multiscale and wavelet based signal processing for electrophysiological and optical brain imaging
用于电生理学和光学脑成像的多尺度和基于小波的信号处理
- 批准号:
238902-2012 - 财政年份:2013
- 资助金额:
$ 1.75万 - 项目类别:
Discovery Grants Program - Individual
Multiscale and wavelet based signal processing for electrophysiological and optical brain imaging
用于电生理学和光学脑成像的多尺度和基于小波的信号处理
- 批准号:
238902-2012 - 财政年份:2012
- 资助金额:
$ 1.75万 - 项目类别:
Discovery Grants Program - Individual
Signaux bioélectriques et problèmes inverses en imagerie fonctionnelle cérébrale
大脑图像功能中的生物电信号和反问题
- 批准号:
238902-2007 - 财政年份:2011
- 资助金额:
$ 1.75万 - 项目类别:
Discovery Grants Program - Individual
Signaux bioélectriques et problèmes inverses en imagerie fonctionnelle cérébrale
大脑图像功能中的生物电信号和反问题
- 批准号:
238902-2007 - 财政年份:2010
- 资助金额:
$ 1.75万 - 项目类别:
Discovery Grants Program - Individual
相似海外基金
Rhythmic and arrhythmic brain activity: from advanced signal processing tools to new electromagnetic neuroimaging methods
节律和心律失常的大脑活动:从先进的信号处理工具到新的电磁神经成像方法
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RGPIN-2017-05960 - 财政年份:2021
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$ 1.75万 - 项目类别:
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- 批准号:
RGPIN-2017-05960 - 财政年份:2020
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$ 1.75万 - 项目类别:
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Tools for parameterizing and visualizing electrophysiological rhythmic and arrhythmic features
用于参数化和可视化电生理节律和心律失常特征的工具
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10433968 - 财政年份:2019
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Tools for parameterizing and visualizing electrophysiological rhythmic and arrhythmic features
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Tools for parameterizing and visualizing electrophysiological rhythmic and arrhythmic features
用于参数化和可视化电生理节律和心律失常特征的工具
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用于参数化和可视化电生理节律和心律失常特征的工具
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- 批准号:
RGPIN-2017-05960 - 财政年份:2018
- 资助金额:
$ 1.75万 - 项目类别:
Discovery Grants Program - Individual
Rhythmic and arrhythmic brain activity: from advanced signal processing tools to new electromagnetic neuroimaging methods
节律和心律失常的大脑活动:从先进的信号处理工具到新的电磁神经成像方法
- 批准号:
RGPIN-2017-05960 - 财政年份:2017
- 资助金额:
$ 1.75万 - 项目类别:
Discovery Grants Program - Individual