Nickel-Catalyzed Synthesis and N-Arylation of Biologically Active Sulfonamides
镍催化生物活性磺酰胺的合成和 N-芳基化
基本信息
- 批准号:542827-2019
- 负责人:
- 金额:$ 1.82万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Engage Grants Program
- 财政年份:2019
- 资助国家:加拿大
- 起止时间:2019-01-01 至 2020-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The majority of pharmaceutical compounds derive their beneficial properties from the presence of nitrogen-containing functional groups, including the sulfonamide structural motif. This collaborative research project will seek to exploit recent expertise in sustainable catalysis developed by the applicant's research group, in addressing specific unmet challenges faced by the industrial partner (ParazaPharma Inc., Montreal, QC) with regard to the targeted synthesis and/or modification of biologically active sulfonamide compounds within proprietary active pharmaceutical ingredients. In particular, the industrial partner requires mild routes to biologically active sulfonamides, as well as the N-functionalization of such compounds, ideally exploiting cheap and abundant reagents (e.g., amines, (hetero)aryl chlorides), and making use of Earth abundant catalysts (rather than precious metal catalysts). Once developed, these synthetic protocols can be exploited directly by scientists at ParazaPharma Inc. in proprietary API synthesis/drug development. Success in this project will greatly accelerate the industrial partner's drug development program, thereby leading to more rapid identification of novel therapies to the benefit of all Canadians.
大多数药物化合物从含氮官能团(包括磺酰胺结构基序)的存在获得其有益性质。该合作研究项目将寻求利用申请人研究小组开发的可持续催化方面的最新专业知识,以解决工业合作伙伴(ParazaPharma Inc.,Montreal,QC)关于专有活性药物成分内的生物活性磺酰胺化合物的靶向合成和/或修饰。特别是,工业合作伙伴需要温和的路线来获得具有生物活性的磺胺类化合物,以及此类化合物的N-官能化,最好利用廉价且丰富的试剂(例如,胺、(杂)芳基氯化物),并利用富含地球的催化剂(而不是贵金属催化剂)。一旦开发出来,这些合成方案可以直接由ParazaPharma Inc.的科学家开发。专利API合成/药物开发。该项目的成功将大大加快工业合作伙伴的药物开发计划,从而更快地确定新的疗法,造福所有加拿大人。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Stradiotto, Mark其他文献
Palladium-catalyzed synthesis of indoles via ammonia cross-coupling-alkyne cyclization
- DOI:
10.1039/c1cc11874a - 发表时间:
2011-01-01 - 期刊:
- 影响因子:4.9
- 作者:
Alsabeh, Pamela G.;Lundgren, Rylan J.;Stradiotto, Mark - 通讯作者:
Stradiotto, Mark
Sequential one-pot three-step synthesis of polysubstituted 4-(5-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-1,2,3-triazole systems
- DOI:
10.1039/c7ra07960e - 发表时间:
2017-01-01 - 期刊:
- 影响因子:3.9
- 作者:
Bonacorso, Helio G.;Dal Forno, Gean M.;Stradiotto, Mark - 通讯作者:
Stradiotto, Mark
Intramolecular Hydroamination of Unactivated Alkenes with Secondary Alkyl- and Arylamines Employing [Ir(COD)Cl]2 as a Catalyst Precursor
- DOI:
10.1021/ol900174f - 发表时间:
2009-03-19 - 期刊:
- 影响因子:5.2
- 作者:
Hesp, Kevin D.;Stradiotto, Mark - 通讯作者:
Stradiotto, Mark
[Ir(COD)Cl]2 as a Catalyst Precursor for the Intramolecular Hydroamination of Unactivated Alkenes with Primary Amines and Secondary Alkyl- or Arylamines: A Combined Catalytic, Mechanistic, and Computational Investigation
- DOI:
10.1021/ja908316n - 发表时间:
2010-01-13 - 期刊:
- 影响因子:15
- 作者:
Hesp, Kevin D.;Tobisch, Sven;Stradiotto, Mark - 通讯作者:
Stradiotto, Mark
A P,N-Ligand for Palladium-Catalyzed Ammonia Arylation: Coupling of Deactivated Aryl Chlorides, Chemoselective Arylations, and Room Temperature Reactions
- DOI:
10.1002/anie.201000526 - 发表时间:
2010-01-01 - 期刊:
- 影响因子:16.6
- 作者:
Lundgren, Rylan J.;Peters, Brendan D.;Stradiotto, Mark - 通讯作者:
Stradiotto, Mark
Stradiotto, Mark的其他文献
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{{ truncateString('Stradiotto, Mark', 18)}}的其他基金
Innovations in Cross-coupling via Mechanistically Guided Base-Metal Catalyst Design
通过机械引导的贱金属催化剂设计实现交叉偶联创新
- 批准号:
RGPIN-2019-04288 - 财政年份:2022
- 资助金额:
$ 1.82万 - 项目类别:
Discovery Grants Program - Individual
Exploiting Nickel Cross-coupling Catalysis for the Practical Synthesis and Functionalization of Pharmaceutically Relevant Organic Molecules
利用镍交叉偶联催化进行药物相关有机分子的实际合成和功能化
- 批准号:
561675-2021 - 财政年份:2021
- 资助金额:
$ 1.82万 - 项目类别:
Alliance Grants
Innovations in Cross-coupling via Mechanistically Guided Base-Metal Catalyst Design
通过机械引导的贱金属催化剂设计实现交叉偶联创新
- 批准号:
RGPIN-2019-04288 - 财政年份:2021
- 资助金额:
$ 1.82万 - 项目类别:
Discovery Grants Program - Individual
The pursuit of an expedient route to a proprietary agrochemical intermediate based on chemoselective metal-catalyzed alpha arylation
寻求基于化学选择性金属催化α芳基化的专有农用化学中间体的便捷途径
- 批准号:
566272-2021 - 财政年份:2021
- 资助金额:
$ 1.82万 - 项目类别:
Alliance Grants
Innovations in Cross-coupling via Mechanistically Guided Base-Metal Catalyst Design
通过机械引导的贱金属催化剂设计实现交叉偶联创新
- 批准号:
RGPIN-2019-04288 - 财政年份:2020
- 资助金额:
$ 1.82万 - 项目类别:
Discovery Grants Program - Individual
Innovations in Cross-coupling via Mechanistically Guided Base-Metal Catalyst Design
通过机械引导的贱金属催化剂设计实现交叉偶联创新
- 批准号:
RGPIN-2019-04288 - 财政年份:2019
- 资助金额:
$ 1.82万 - 项目类别:
Discovery Grants Program - Individual
Advancing Late Metal Catalysis: DalPhos Ligand Design, Mechanism, and New Reactivity
推进晚期金属催化:DalPhos 配体设计、机制和新反应性
- 批准号:
RGPIN-2014-04807 - 财政年份:2018
- 资助金额:
$ 1.82万 - 项目类别:
Discovery Grants Program - Individual
Advancing Late Metal Catalysis: DalPhos Ligand Design, Mechanism, and New Reactivity
推进晚期金属催化:DalPhos 配体设计、机制和新反应性
- 批准号:
RGPIN-2014-04807 - 财政年份:2017
- 资助金额:
$ 1.82万 - 项目类别:
Discovery Grants Program - Individual
Advancing Late Metal Catalysis: DalPhos Ligand Design, Mechanism, and New Reactivity
推进晚期金属催化:DalPhos 配体设计、机制和新反应性
- 批准号:
RGPIN-2014-04807 - 财政年份:2016
- 资助金额:
$ 1.82万 - 项目类别:
Discovery Grants Program - Individual
Multi-User Ultra High Performance Liquid Chromatography/Mass Spectrometry Instrument for High-Throughput Analysis
用于高通量分析的多用户超高性能液相色谱/质谱仪
- 批准号:
RTI-2017-00320 - 财政年份:2016
- 资助金额:
$ 1.82万 - 项目类别:
Research Tools and Instruments
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