Investigating the role of the unfolded protein response at early and late stages of pancreatic ductal adenocarcinoma

研究未折叠蛋白反应在胰腺导管腺癌早期和晚期的作用

• 批准号: 428961
• 负责人: Martin Mickenzie B
• 金额: $ 1.27万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-12-01 至 2020-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=428961&lang=en
• 关键词: Acinar To Ductal Metaplasia; Activating Transcription Factor 3; Cancer; Chemotherapy Resistance; Chronic Pancreatitis; Er Stress Response; Exocrine Pancreas; Gastroenterology; Pancreatic Ductal Adenocarcinoma; Unfolded Protein Response

"Pancreatic cancer is a devastating cancer with only 8% of those diagnosed surviving past 5 years. My project wants to answer how the unfolded protein response (UPR), a cellular stress response, functions at both the beginning stages and stage after a tum

“胰腺癌是一种毁灭性的癌症，只有8%的人在过去5年中存活。我的项目想回答未折叠蛋白反应（UPR），一种细胞应激反应，在开始阶段和转化后阶段是如何起作用的。