Regulation of innate immunity and tumour progression by activating transcription factor 3

通过激活转录因子 3 调节先天免疫和肿瘤进展

• 批准号: nhmrc : 1006588
• 负责人: Dr Dakang Xu
• 金额: $ 31.57万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-innate-immunity-factor-3/109196
• 关键词: Regulation; innate; immunity; tumour; progression

Toll-like receptors (TLRs) play an essential role in innate immune responses and are involved in initiating tumourigenesis via inflammatory pathways. We have shown that the transcription factor ATF3 is a negative regulator of TLR signalling. We will study how modulation of the activity of ATF3 affects the inflammatory response and tumour progression. This will provide a molecular basis on which to design therapeutic reagents for the treatment of cancer.

Toll样受体（TLR）在先天免疫应答中起重要作用，并通过炎症途径参与启动肿瘤发生。我们已经表明，转录因子ATF3是TLR信号传导的负调节因子。我们将研究ATF3活性的调节如何影响炎症反应和肿瘤进展。这将为设计用于治疗癌症的治疗试剂提供分子基础。