Advanced Microfluidic Nanobiosensing

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The demands for continuously improving current analytical platforms (e.g., in terms of lower cost, higher performance, and better accessibility) require new biosensing technologies to be developed for applications such as molecular diagnosis, environmental monitoring, and food testing. Microfluidic and lab-on-a-chip technologies hold great promise for creating powerful biosensing platforms because of their unique capabilities such as parallel sample manipulation, on-chip biosensor integration, and sensitive analyte detection. This research program aims to develop new microfluidic nanobiosensing technologies that integrate two newly emerging nanomaterials - nanofibrillated cellulose (NFC) and molybdenum disulfide (MoS2). The research will focus on design and microfabrication of novel nanobiosensors, on-chip synthesis and integration of functional nanomaterials, investigation of new bioanalytical methods, and optimization and characterization of device performance. The proposed biosensing platforms will inherit the advantages of microfluidic devices and nanomaterial-based biosensors, and thus further advance the state of the art of biosensing technologies. ******This program will lead to innovative nanobiosensing technologies, new theoretical models and design guidelines, and first-of-their-kinds nanobiosensor prototypes suitable for practical applications. These high-performance biosensing platforms will find immediate applications in medical diagnosis and water/food testing, thus benefiting the health and economy of Canadian society. This program will also provide interdisciplinary training for 17 highly qualified personnel (4 Ph.D. students, 3 master's students, and 10 undergraduate students) and equip them with academic and professional skills required to apply the gained knowledge for long-term impact and lead new initiatives in microfluidics and biosensing.