High resolution multimodal SPR imaging instrumentation for the development of cell-based photonics biosensors
用于开发基于细胞的光子生物传感器的高分辨率多模态 SPR 成像仪器
基本信息
- 批准号:RGPIN-2015-05188
- 负责人:
- 金额:$ 3.24万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2019
- 资助国家:加拿大
- 起止时间:2019-01-01 至 2020-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Biosensors, also known as labs-on-a-chip, are bioanalytical devices designed for use in personalized medicine, rapid medical diagnostics, drug discovery and environmental analysis. Most biosensors work by chemically detecting specific "biomolecular markers" such as pathogens or environmental contaminants. There are many applications, however, for which no reliable markers can be found. In such cases, "higher-level" biosensors based on live biological cells are a powerful alternative. Indeed, cells are complex self-contained miniaturized machines that can be used as the basis for biosensing, where the cell response to its environment is in itself the sensing mechanism. Recent advances in nanotechnology and theoretical understanding of sub-wavelength phenomena in plasmonics have opened up many new and exciting possibilities for miniaturized biosensing. My research program over the next 5 years seeks to capitalize on these advances by developing novel high-resolution multi-modal instrumentation designed to discover new enabling knowledge on how cells react to changes in their local environment in response to the presence of disease factors, pathogens, or contaminants. This new knowledge will lead to the development of next-generation cell-based biosensors designed to address some of the most pressing needs in critical care and personalized medicine.*** **
生物传感器,也被称为芯片上的实验室,是设计用于个性化医疗、快速医疗诊断、药物发现和环境分析的生物分析设备。大多数生物传感器的工作原理是化学检测特定的“生物分子标记”,如病原体或环境污染物。然而,有许多应用无法找到可靠的标记。在这种情况下,基于活生物细胞的“高级”生物传感器是一个强大的选择。事实上,细胞是复杂的自包含的微型机器,可以用作生物传感的基础,细胞对其环境的反应本身就是传感机制。纳米技术的最新进展和对等离子体亚波长现象的理论理解为微型生物传感开辟了许多新的令人兴奋的可能性。在接下来的5年里,我的研究计划寻求通过开发新型高分辨率多模态仪器来利用这些进步,这些仪器旨在发现新的知识,了解细胞如何对当地环境的变化做出反应,以响应疾病因素、病原体或污染物的存在。这一新知识将导致下一代基于细胞的生物传感器的发展,旨在解决危重病护理和个性化医疗中一些最紧迫的需求。* * * * *
项目成果
期刊论文数量(0)
专著数量(0)
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Charette, Paul其他文献
Charette, Paul的其他文献
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{{ truncateString('Charette, Paul', 18)}}的其他基金
High resolution multimodal SPR imaging instrumentation for the development of cell-based photonics biosensors
用于开发基于细胞的光子生物传感器的高分辨率多模态 SPR 成像仪器
- 批准号:
RGPIN-2015-05188 - 财政年份:2022
- 资助金额:
$ 3.24万 - 项目类别:
Discovery Grants Program - Individual
NSERC/Teledyne DALSA Industrial Research Chair in Next Generation MEMS and Microphotonics
NSERC/Teledyne DALSA 下一代 MEMS 和微光子学工业研究主席
- 批准号:
548601-2018 - 财政年份:2021
- 资助金额:
$ 3.24万 - 项目类别:
Industrial Research Chairs
High resolution multimodal SPR imaging instrumentation for the development of cell-based photonics biosensors
用于开发基于细胞的光子生物传感器的高分辨率多模态 SPR 成像仪器
- 批准号:
RGPIN-2015-05188 - 财政年份:2021
- 资助金额:
$ 3.24万 - 项目类别:
Discovery Grants Program - Individual
High resolution multimodal SPR imaging instrumentation for the development of cell-based photonics biosensors
用于开发基于细胞的光子生物传感器的高分辨率多模态 SPR 成像仪器
- 批准号:
RGPIN-2015-05188 - 财政年份:2020
- 资助金额:
$ 3.24万 - 项目类别:
Discovery Grants Program - Individual
NSERC/Teledyne DALSA Industrial Research Chair in Next Generation MEMS and Microphotonics
NSERC/Teledyne DALSA 下一代 MEMS 和微光子学工业研究主席
- 批准号:
548601-2018 - 财政年份:2020
- 资助金额:
$ 3.24万 - 项目类别:
Industrial Research Chairs
NSERC/Teledyne DALSA Industrial Research Chair in Next Generation MEMS and Microphotonics
NSERC/Teledyne DALSA 下一代 MEMS 和微光子学工业研究主席
- 批准号:
548601-2018 - 财政年份:2019
- 资助金额:
$ 3.24万 - 项目类别:
Industrial Research Chairs
Conception d'un fluorimètre haute performance à base de système optique intégré et d'électronique faible bruit
荧光高级性能的概念以及光学集成系统和电子故障的基础
- 批准号:
522759-2018 - 财政年份:2018
- 资助金额:
$ 3.24万 - 项目类别:
Engage Grants Program
Conception d'un fluorimètre haute performance à base de système optique intégré et d'électronique faible bruit
荧光高级性能的概念以及光学集成系统和电子故障的基础
- 批准号:
535946-2018 - 财政年份:2018
- 资助金额:
$ 3.24万 - 项目类别:
Engage Plus Grants Program
High resolution multimodal SPR imaging instrumentation for the development of cell-based photonics biosensors
用于开发基于细胞的光子生物传感器的高分辨率多模态 SPR 成像仪器
- 批准号:
RGPIN-2015-05188 - 财政年份:2018
- 资助金额:
$ 3.24万 - 项目类别:
Discovery Grants Program - Individual
Fabrication à grande échelle de capteurs d'imagerie infra-rouge à haute performance
制作 à grande échelle de capteurs dimagerie infra-rouge à 高级性能
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523849-2018 - 财政年份:2018
- 资助金额:
$ 3.24万 - 项目类别:
Synergy Awards
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