High resolution multimodal SPR imaging instrumentation for the development of cell-based photonics biosensors

用于开发基于细胞的光子生物传感器的高分辨率多模态 SPR 成像仪器

基本信息

批准号：
RGPIN-2015-05188
负责人：
Charette, Paul
金额：
$ 3.24万
依托单位：
Université de Sherbrooke
依托单位国家：
加拿大
项目类别：
Discovery Grants Program - Individual
财政年份：
2022
资助国家：
加拿大
起止时间：
2022-01-01 至 2023-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=754110
关键词：
resolution multimodal SPR imaging instrumentation

项目摘要

Biosensors, also known as labs-on-a-chip, are bioanalytical devices designed for use in personalized medicine, rapid medical diagnostics, drug discovery and environmental analysis. Most biosensors work by chemically detecting specific "biomolecular markers" such as pathogens or environmental contaminants. There are many applications, however, for which no reliable markers can be found. In such cases, "higher-level" biosensors based on live biological cells are a powerful alternative. Indeed, cells are complex self-contained miniaturized machines that can be used as the basis for biosensing, where the cell response to its environment is in itself the sensing mechanism. Recent advances in nanotechnology and theoretical understanding of sub-wavelength phenomena in plasmonics have opened up many new and exciting possibilities for miniaturized biosensing. My research program over the next 5 years seeks to capitalize on these advances by developing novel high-resolution multi-modal instrumentation designed to discover new enabling knowledge on how cells react to changes in their local environment in response to the presence of disease factors, pathogens, or contaminants. This new knowledge will lead to the development of next-generation cell-based biosensors designed to address some of the most pressing needs in critical care and personalized medicine.

生物传感器，也称为片上实验室，是旨在用于个性化医学，快速医学诊断，药物发现和环境分析的生物分析设备。大多数生物传感器通过化学检测特定的“生物分子标记”（例如病原体或环境污染物）来起作用。但是，在许多应用程序中找不到可靠的标记。在这种情况下，基于实时生物细胞的“高级”生物传感器是一种有力的选择。实际上，细胞是复杂的独立小型机器，可以用作生物传感的基础，其中细胞对环境的响应本身就是感应机制。纳米技术的最新进展和对次波长现象的理论理解为小型生物传感开辟了许多新的令人兴奋的可能性。我未来5年的研究计划试图通过开发新型的高分辨率多模式仪器来利用这些进步，旨在发现有关细胞对疾病因素，病原体或污染物的存在如何反应其本地环境变化的新知识。这些新知识将导致下一代基于细胞的生物传感器的发展，旨在满足重症监护和个性化医学中一些最紧迫的需求。