Advanced Magnetic Resonance Techniques for Rapid Non-Invasive Monitoring of Neuromuscular Activity

用于快速无创监测神经肌肉活动的先进磁共振技术

• 批准号: RGPIN-2017-06318
• 负责人: Noseworthy, Michael
• 金额: $ 3.35万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=689201
• 关键词: Advanced; Magnetic; Resonance; Techniques; Rapid

The proposed project focuses on the evaluation of skeletal muscle, exercise, and brain-muscle interaction. In an unprecedented fashion brain and muscle will be evaluated with functional magnetic resonance imaging (fMRI, based on the blood-oxygen level dependent (BOLD) signal) methods prior to, during and after exercise. In addition, electromyography (EMG) and electroencephalography (EEG) will be done concurrent with MRI to record electrical activity in both tissues. Also, because the movement of sodium ions (Na+) in and out of cells is one of the driving forces of electrical activity in the tissues, intra and extracellular muscle (Nai Nae) will be related in brain to EEG and in muscle to changing EMG activity. This highly innovative project is unique due to use of an in-bore MRI compatible Lode cycle ergometer, MRI compatible 64 channel EEG and 8 channel EMG systems. Furthermore, no research has ever been performed to concurrently assess human brain/muscle activity during exercise.***Long term Goals:***1) To understand how skeletal muscle BOLD and Nai Nae signals relate to muscle electrical activity, measured using EMG. ***2) To determine how motion contributes to and can be corrected for in muscle BOLD signals.***3) To understand spatially and temporally localized changes in brain function (fMRI, EEG and Nai/Nae) when activating skeletal muscle with differing kinds of exercise. ***4) To temporally correlate brain activity from EEG, fMRI and Nai/Nae MRI with muscle EMG, BOLD and Nai Nae signals, and under various exercise paradigms. ***5) To determine spatial and temporal correlations between brain and muscle activation during exercise, when comparing muscle extension and flexion, and isometric and isokinetic force.***Objectives: ***1) Development of non-invasive MRI approaches to temporally assess physiology in vivo.***2) To enhanced the speed at which these measures can be performed***3) To develop novel methods that can corroborate MRI measures.***Summary of Scientific Approach:***BOLD MR imaging, and Na-MRI measures will be performed in brain and leg skeletal muscles before, during and following a range of exercise paradigms (isometric and isokinetic) with differing load/intensity, in healthy volunteers. Correlation and coherence analysis will be done to compare tissue BOLD and EMG activity. Muscle spatial activation will be compared to temporal changes in brain activation. Accelerated Na-MRI acquisition speed will be done using phased array RF coils and compressed sensing.

拟议的项目侧重于骨骼肌，运动和脑肌肉相互作用的评估。 在一个前所未有的方式，大脑和肌肉将评估功能磁共振成像（fMRI，基于血氧水平依赖（BOLD）信号）的方法之前，期间和之后的运动。 此外，肌电图（EMG）和脑电图（EEG）将与MRI同时进行，以记录两种组织中的电活动。 此外，由于钠离子（Na+）进出细胞的运动是组织中电活动的驱动力之一，因此内部和细胞外肌肉（Nai Nae）将在大脑中与EEG相关，并且在肌肉中与改变EMG活动相关。 这个高度创新的项目是独一无二的，因为它使用了一个与MRI兼容的矿脉测力计，与MRI兼容的64通道EEG和8通道EMG系统。 此外，还没有研究同时评估人类大脑/肌肉在运动中的活动。长期目标：*1）了解骨骼肌BOLD和Nai Nae信号如何与肌电活动相关，使用EMG测量。 *2）确定运动如何影响肌肉BOLD信号并对其进行校正。* 3)了解不同类型运动激活骨骼肌时脑功能（fMRI、EEG和Nai/Nae）的空间和时间局部变化。*4）在时间上将来自EEG、fMRI和Nai/Nae MRI的脑活动与肌肉EMG、BOLD和Nai Nae信号以及在各种锻炼范例下相关联。*5）确定运动期间大脑和肌肉激活之间的空间和时间相关性，当比较肌肉伸展和屈曲以及等长和等速力时。目的：*1）开发非侵入性MRI方法，以暂时评估体内生理学。* 2)提高这些测量的速度 *3）开发新的方法来证实MRI测量。科学方法总结：* 在健康志愿者中，在不同负荷/强度的一系列运动模式（等长和等速）之前、期间和之后，将对大脑和腿部骨骼肌进行BOLD MR成像和Na-MRI测量。将进行相关性和相干性分析以比较组织BOLD和EMG活动。肌肉空间激活将与大脑激活的时间变化进行比较。将使用相控阵RF线圈和压缩传感来加速Na-MRI采集速度。