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Oxidative stress in the endoplasmic reticulum and its impact on liver inflammation in an aging mouse model

Oxidative stress in the endoplasmic reticulum and its impact on liver inflammation in an aging mouse model
衰老小鼠模型中内质网的氧化应激及其对肝脏炎症的影响
批准号：
418674
负责人：
Lebel Michel
金额：
$47.37万
依托单位：
Centre hospitalier de l'Universit Laval (Qubec)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2020
资助国家：
加拿大
项目状态：
未结题
起止时间：
2020-03-01 至 2025-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=418674&lang=en
关键词：
Aging Chemical Chaperones Endoplasmic Reticulum Inflammation Knockout Mice Liver Non-Alcoholic Fatty Liver Disease Oxidative Stress Unfolded Protein Response Werner Syndrome

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英文摘要
A recurrent theme associated with aging processes is an increase cellular oxidative stress. In addition, a chronic low-grade systemic inflammation occurring in the absence of infection has been defined as "inflammaging" and represents a significant risk f
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Molecular aging: Mouse molecular models for Werner syndrome.
Identification of microRNAs important for the lifespan of animal models for the premature aging Werner syndrome.
  • 批准号：
    228759
  • 项目类别：
    Operating Grants
  • 资助金额：
    $3.64万
  • 财政年份：
    2010
  • 负责人：
    Lebel Michel
  • 依托单位：
    Universit Laval
Understanding the molecular role of the Werner syndrome gene product in preventing aging disorders in the general population.
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