Development of a synthetic cannabinoid program

本研究计划是关于开发一个完全合成的化学平台来获取大麻二酚（CBD）。CBD是大麻（大麻sativa）树脂中的一种次要成分，没有精神活性，也不会上瘾。CBD在治疗方面的应用越来越多，例如偏头痛和神经性疼痛等疼痛管理，以及癫痫和癫痫发作的治疗。虽然天然大麻树脂预计将于2018年10月17日推迟，但获得合成CBD缓解了不断增长的大麻产业面临的许多问题（成本、水平不一致、真菌和昆虫侵扰等）。可靠的大麻二酚合成途径将允许可靠的生产和制备类似物，这将允许对这种非阿片类镇痛药的疼痛管理适应症进行彻底调查。

This research proposal is concerned with the development of a totally synthetic chemical platform to access cannabidiol (CBD). CBD is a minor constituent in cannabis (Cannabis sativa) resin and is non-psychoactive and non-addictive. CBD has a growing list of therapeutic applications, for example in pain management such as migraine and neuropathic pain, as well as treatment of epilepsy and seizures. While natural cannabis resin is expected to be descheduled on October 17th 2018, access to synthetic CBD alleviates many of the problems (cost, inconsistent levels, fungal and insect infestations etc) faced in the growing cannabis industry. Reliable synthetic access to CBD will allow for reliable production and preparation of analogs that will permit a thorough investigation into the pain-management indications of this non-opiate based analgesic.