Development of new Synthons, Catalysts and Applications in Organic Synthesis

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This program of research concerns the development of methods that utilize relatively inexpensive, available building block chemicals known as olefins and olefin derivatives, using catalytic techniques, such as transition metal catalysis and organocatalysis, and to convert these building blocks to high value chiral intermediates using asymmetric cycloaddition reactions. The products of these reactions are either directly useful as, or may be conveniently converted to, biologically active natural products and/or derivatives thereof.***These include, but are not limited to, anticancer agents, antiviral agents, anti-parasitic agents. In addition to these applied aspects, the general synthesis of cyclobutanes, cyclpentanes and cyclohexanes is of general importance in view of the occurrence of these core features across the spectrum of natural and non-natural organic compounds and in materials. The methods to access chiral functionalized versions of the core molecules will be researched in detail. The methods developed here allow access to highly functionalized variations of each core in and asymmetric fashion and hence the work is of general importance in advancing synthetic methodology applicable to many fields. Applications of the methodology include opening routes to building block chemicals produced by Canadian industry and applications of the methods apply to high-value pharmaceuticals of use in a variety of areas extending beyond the scope of the grant. Work in this area allows for the training of highly qualified researchers to gain skills and experience and to translate those skills to industrial, academic and institutions where they are in very high demand.