Prenatal alcohol/cannabinoid co-exposures and fetal brain development

产前酒精/大麻素共同暴露与胎儿大脑发育

• 批准号: 10517743
• 负责人: Kirill V Larin
• 金额: $ 1.46万
• 依托单位: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10517743
• 关键词: Alcohol abuse; Alcohols; Angiography; Area; Award; Behavioral; Biological Assay; Biophysics; Blood Vessels; Blood flow; Brain; Cannabinoids; Cells; Cerebrovascular Circulation; Collaborations; Communication; Complement; Data Analyses; Development; Dose; Drug abuse; Embryo; Ensure; Ethanol; Experimental Designs; Exposure to; Female; Fluorescence; Goals; Growth; Health; Image; Imaging Techniques; Imaging technology; Laboratories; Light; Long-Term Effects; Mentors; Mentorship; Microscopy; Multimodal Imaging; Mus; National Institute on Alcohol Abuse and Alcoholism; Neonatal; Optical Coherence Tomography; Optics; Parents; Physiological; Physiology; Process; Protocols documentation; Publishing; Reporter; Research; Research Personnel; Research Project Grants; Stains; Tomatoes; Training; Ultrasonography; Writing; alcohol effect; alcohol exposure; alcohol research; angiogenesis; base; behavioral outcome; biomedical imaging; career; experimental study; fetal; fluorescence imaging; high resolution imaging; imaging approach; in utero; in vivo; male; multidisciplinary; nerve stem cell; offspring; optical imaging; parent grant; prenatal; research and development; response; skills; synthetic cannabinoid; tool; vasculogenesis

PROJECT SUMMARY This is an application in response to NIAAA Research Supplements to Promote Diversity in Health-Related Research. The candidate's research will be within the scope of the parent award: the utilization of optical noninvasive and high-resolution imaging technology to assess the effects of ethanol and cannabinoid exposure on fetal brain growth and analyze the changes in the vasculature supporting brain development. Complementing the approach described in the parent grant, the candidate will perform additional experiments of embryonic imaging using fluorescence and ultrasound imaging techniques for corroboration with the ongoing and already published Optical Coherence Tomography (OCT)-imaged results. The candidate's training plan includes the development of research, communication, and writing skills and extensive training in physiology and biophysics of alcohol and drug abuse. .

项目摘要 这是一个应用程序，以响应NIAAA研究补充，以促进多样性， 健康相关的研究。候选人的研究将在父母奖的范围内： 利用光学非侵入性和高分辨率成像技术来评估效果 乙醇和大麻素暴露对胎儿脑生长的影响，并分析 支持大脑发育的血管系统作为对母公司所述方法的补充， 格兰特，候选人将进行额外的实验，胚胎成像使用荧光 和超声成像技术，以证实正在进行的和已经发表的 光学相干断层扫描（OCT）-成像结果。 候选人的培训计划包括研究、交流和写作的发展 酒精和药物滥用生理学和生物物理学方面的技能和广泛培训。 .