Cell Stress and Inflammation

细胞压力和炎症

• 批准号: 1000232202-2018
• 负责人: Logue, Susan
• 金额: $ 8.74万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=693109
• 关键词: Cell; Stress; Inflammation

To function properly proteins must be folded into the correct shape. Sometimes protein folding does not occur correctly and misfolded proteins accumulate. If prolonged or extensive, this leads to cell death. Stress responses help lower the level of misfolded proteins. Recent evidence suggests stress responses can also alter cell-to-cell communication but we do not understand how. This research program asks how stressed cells communicate with and influence their neighbouring cells. This knowledge will greatly increase our understanding of cellular stress responses in the context of the body as a whole, and not as isolated events occurring in single, stressed cells.

蛋白质必须折叠成正确的形状才能正常工作。有时蛋白质折叠不正确，错误折叠的蛋白质会积累。如果延长或广泛，这将导致细胞死亡。应激反应有助于降低错误折叠蛋白质的水平。最近的证据表明，压力反应也可以改变细胞与细胞的交流，但我们不知道如何。这项研究计划询问应激细胞如何与相邻细胞沟通并影响它们。这一知识将大大增加我们对细胞应激反应的理解，而不是将其视为发生在单个应激细胞中的孤立事件。