Endogenous Repair

内源性修复

• 批准号: 1000231201-2015
• 负责人: Gilbert, Penney
• 金额: $ 8.74万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=693154
• 关键词: Endogenous; Repair

Every two minutes one Canadian over the age of 65 will experience a fall-related injury. Frequently this results in hospitalization, loss of independence, or in some cases, death. The goal of the proposed CRC research program is to develop therapeutics that increase muscle strength after injury as a strategy to overcome a risk factor of senior falls. To achieve this goal, Dr. Gilbert will use unbiased screening and hypothesis-driven research to identify molecules that target and rejuvenate muscle stem cells within aging skeletal muscle. She will also engineer a device with miniaturized human skeletal muscle tissues for compound screening.

每两分钟就有一名65岁以上的加拿大人遭受与跌倒相关的伤害。这通常导致住院治疗，失去独立性，或在某些情况下，死亡。拟议的CRC研究计划的目标是开发增加受伤后肌肉力量的治疗方法，作为克服老年福尔斯风险因素的策略。为了实现这一目标，吉尔伯特博士将使用无偏见的筛选和假设驱动的研究，以确定分子的目标和振兴肌肉干细胞老化骨骼肌。她还将设计一种带有微型人体骨骼肌组织的设备，用于化合物筛选。