Nanosafety in Food

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The proposed research program aims to determine the safety of dietary engineered nanomaterials (ENMs) by addressing current knowledge gaps on their fate, transformation, toxicity and exposure level. Specific aims are to, (i) determine the transformation (change in physicochemical properties) of ENMs when exposed to food processing, storage and physiological conditions, and determine its consequence on nano-bio interactions, (ii) determine gastrointestinal toxicity of ENMs through next-generation toxicology approach that take advantage of advancements in toxicology (adverse outcome pathways), high-throughput-screening platforms and computational tools, and (iii) develop exposure assessment matrix for ENMs by integrating analytical instrumentation.