Nanosafety in Food

拟议的研究计划旨在通过解决目前关于膳食工程纳米材料(ENM)的命运、转化、毒性和暴露水平的知识空白来确定其安全性。具体目标是：(I)确定ENMS在食品加工、储存和生理条件下的转化(物理化学性质的变化)，并确定其对纳米生物相互作用的后果；(Ii)通过利用毒理学(不良后果途径)、高通量筛选平台和计算工具的新一代毒理学方法确定ENMS的胃肠道毒性；以及(Iii)通过整合分析仪器开发ENMS的暴露评估矩阵。

The proposed research program aims to determine the safety of dietary engineered nanomaterials (ENMs) by addressing current knowledge gaps on their fate, transformation, toxicity and exposure level. Specific aims are to, (i) determine the transformation (change in physicochemical properties) of ENMs when exposed to food processing, storage and physiological conditions, and determine its consequence on nano-bio interactions, (ii) determine gastrointestinal toxicity of ENMs through next-generation toxicology approach that take advantage of advancements in toxicology (adverse outcome pathways), high-throughput-screening platforms and computational tools, and (iii) develop exposure assessment matrix for ENMs by integrating analytical instrumentation.