Quantitative Cell Biology and Morphogenesis

定量细胞生物学和形态发生

• 批准号: CRC-2016-00235
• 负责人: FernandezGonzalez, Rodrigo
• 金额: $ 8.74万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=693267
• 关键词: Quantitative; Cell; Biology; Morphogenesis

In animals, cells coordinate their behaviours and move in groups to form, repair or invade tissues. The mechanisms used by cells to coordinate their movements are unclear. Increasing evidence indicates that cells sense, transmit and respond to mechanical forces. Dr. Fernandez-Gonzalez will use the collective movements that drive embryonic wound repair in fruit fly embryostogether with live imaging, computational models and a combination of genetic, pharmacological and biophysical manipulationsto understand the physical signals used by cells to communicate their behaviours and coordinate cell migration.

在动物中，细胞协调它们的行为并成群结队地移动以形成、修复或侵入组织。细胞用来协调其运动的机制尚不清楚。越来越多的证据表明，细胞能够感知、传递机械力并对其做出反应。费尔南德斯-冈萨雷斯博士将使用推动果蝇胚胎创伤修复的集体运动，结合实时成像、计算模型和遗传、药理学和生物物理操作的组合，了解细胞用来交流行为和协调细胞迁移的物理信号。