Predoctoral Training in Quantitative Cell & Molecular Biology

项目概要/摘要 定量细胞和分子生物学（qCMB）培训计划将提供全面和灵活的 定量方法的培训，以促进广泛的跨学科和合作研究 细胞与分子生物学领域。该计划将产生优秀的毕业生与技能，以满足 现代生命科学研究的计算和专业需求。目标包括生产 更多的毕业生能够应用计算方法来解决生物学问题，建立和维持一个 提供这方面的培训，鼓励和支持跨学科合作， 提供培训和专业发展机会，使学生更好地为劳动力做好准备， 通过营造一个支持性和包容性的环境来促进完成。 该qCMB计划旨在支持学生参与合作研究项目，需要 生成和分析大型生物数据集，特别是通过测序、成像 和流式细胞仪它结合了最近开发的计算和定量课程， 为该计划开发的门户课程，以及鼓励可重复研究的创新方法。 将通过年度报告、研讨会和委员会会议监测进展情况。学员将 通过个性化的职业指导，沿着专业技能，为进入职场做好准备 培训、行业专业人士的指导和实习经验的指导。 学员将受到欢迎和支持，无论种族，性别，年龄，性取向或残疾。的 该计划将通过同伴指导、年度野餐等既定活动和海报来促进这一点 研讨会我们将通过每月会议和夏季研讨会/务虚会建立一个qCMB社区。 辅导员将通过必要的培训得到支持，这些培训将磨练他们的辅导技能， 确保学员从事可复制研究的战略。现有和新的合作 在单细胞生物学、转录后控制、基因组等领域工作的导师 结构与功能，蛋白质结构与功能将为学生提供参与的机会， 跨学科的定量/计算研究，需要理解细胞和分子 生物学导师指导计划和有效性将由qCMB领导层进行评估。 潜在的学员（每年8-10人）被招募到现有的跨学科细胞和分子生物学博士 计划，并在他们的第一年轮换，以确定一个实验室/导师，适合他们的研究兴趣， 辅导需求。在第一年结束时，将选择三名进入qCMB实验室的学员进行支持 通过这个奖项，每个人将获得两年的支持，然后过渡到导师的研究 补助金或其他奖学金，以获得津贴支持。该奖项将支持总共15名受训人员，他们将过渡到 学术界或行业中需要数据分析、协作和研究经验的职位。

Project Summary/Abstract The Quantitative Cell and Molecular Biology (qCMB) Training Program will provide comprehensive and flexible training in quantitative approaches in order to facilitate transdisciplinary and collaborative research in the broad field of Cell & Molecular Biology. The Program will produce outstanding graduates with the skills to meet the computational and professional demands of modern life science research. The objectives include to produce more graduates able to apply computational approaches to solve biological problems, build and sustain an accessible curriculum to provide training in this area, encourage and support transdisciplinary collaborations, provide training and professional development opportunities to better prepare students for the workforce, and facilitate completion by fostering a supportive and inclusive environment. The qCMB program is designed to support students engaging in collaborative research projects requiring the generation and analysis of large biological datasets particularly those generated through sequencing, imaging and flow cytometry. It combines recently developed computational and quantitative coursework with a new gateway course developed for this program, and innovative approaches to encourage reproducible research. Progress will be monitored through annual reports, seminars and committee meetings. Trainees will be prepared for entry to the workforce through personalized career mentoring, along with professional skills training, mentoring from industry professionals and guided access to internship experiences. Trainees will be welcomed and supported regardless of race, gender, age, sexual orientation or disability. The program will facilitate this through peer mentoring, established events such as an Annual Picnic, and Poster Symposium. We will build a qCMB community through monthly meetings, and a summer symposium/retreat. Preceptors will be supported through required training that will hone their mentoring skills and convey strategies to ensure mentees engage in reproducible research. Existing and new collaborations between preceptors working in areas such as Biology of Single Cells, Post-Transcriptional Control, Genome Architecture & Function, and Protein Structure & Function will provide students with opportunities to engage in transdisciplinary quantitative/computational research that requires comprehension of cell and molecular biology. Preceptor mentoring plans and effectiveness will be evaluated by the qCMB leadership. Potential trainees (8-10 each year) are recruited into the existing interdisciplinary Cell & Molecular Biology PhD Program, and rotate during their first year to identify a lab/preceptor that fits their research interests and mentoring needs. At the end of the first year, three trainees entering qCMB labs will be selected for support through this award and each will be supported for two years before transitioning to the preceptor's research grant or other fellowship for stipend support. The award will support a total of 15 trainees, who will transition to positions in academia, or industry that require data analysis, collaboration and research experience.