Regulatory Genomics

监管基因组学

• 批准号: CRC-2018-00118
• 负责人: Yang, Guang
• 金额: $ 8.74万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=693274
• 关键词: Regulatory; Genomics

A fundamental question in biology is how the information encoded in the genome is accurately interpreted to make the vast diversity of neurons in the mammalian brain required for higher-cognitive function. To properly instruct cell fate decision during neurogenesis, the genome needs to be coordinated at multiple levels and integrate intrinsic and environmental signals to ensure correct expression of genes. The long-term goal of my research program is to address this question, focusing on the translational regulation of the genome. We will define the translational landscape of genome regulation in neurogenesis and dissect the molecular mechanisms underlying this genome regulation.

生物学的一个基本问题是如何准确地解释基因组中编码的信息，以使哺乳动物大脑中的大量神经元具有更高的认知功能所需。为了在神经发生过程中正确指导细胞命运决定，基因组需要在多个层面上进行协调并整合内在和环境信号以确保基因的正确表达。我的研究计划的长期目标是解决这个问题，重点关注基因组的翻译调控。我们将定义神经发生中基因组调控的翻译景观，并剖析这种基因组调控背后的分子机制。