Passive thermal regulator for bio-organisms

生物有机体的被动热调节器

• 批准号: 545136-2019
• 负责人: Siddiqui, Kamran
• 金额: $ 9.06万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Idea to Innovation
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=693363
• 关键词: Passive; thermal; regulator; bio; organisms

Solid organ transplantation is the preferred and sometimes only life saving option for patients with end stage organ failure. The demand for solid organs for transplant is very high and their suitability is heavily dependent on the proper preservation and secure transportation to the transplant centre. The current standard practice is to preserve an organ in specialized cold buffer solutions and transport in cold environment under hypothermic conditions (~4 C). With currently approved portable organ transport devices, cold conditions are maintained using an ice bath, which lacks the ability to actively control the temperature and conduct comprehensive temperature monitoring. Furthermore, recent scientific advancements in the field show that the optimal preservation temperature varies between -6 C to 37 C, which current organ transport devices cannot provide. An innovative temperature-regulating technology has been developed to address the challenges and limitations in the current market of portable organ preservation devices. This innovative technology has the ability to not only control the organ temperature at a certain set-point but also to dynamically adjust the organ's storage temperature over a wide range without any requirements of an external active power source. The unique functionalities provided by this innovative technology would serve as a game changer in the field of organ transportation devices. The objectives of the proposed work are (i) to optimize the overall design of this novel dynamic temperature-regulating device for its utilization in organ transportation system and, (ii) to conduct validation tests using intact organs to demonstrate its effectiveness for potential commercialization.

对于终末期器官衰竭的患者，实体器官移植是首选的，有时也是唯一的挽救生命的选择。对用于移植的实体器官的需求非常高，它们的适用性在很大程度上取决于适当的保存和运往移植中心的安全运输。目前的标准做法是将器官保存在专门的冷缓冲溶液中，并在低温条件下（~4℃）在寒冷环境中运输。目前批准的便携式器官运输设备，使用冰浴来维持寒冷的条件，缺乏主动控制温度和进行全面温度监测的能力。此外，最近该领域的科学进展表明，最佳保存温度在-6℃至37℃之间，这是目前器官运输设备无法提供的。为了解决目前便携式器官保存设备市场的挑战和局限性，开发了一种创新的温度调节技术。这项创新技术不仅可以将器官温度控制在某一设定点，而且可以在不需要外部有源的情况下，在大范围内动态调节器官的储存温度。这项创新技术提供的独特功能将成为器官运输设备领域的游戏规则改变者。这项工作的目标是：(i)优化这种新型动态温度调节装置的整体设计，以便在器官运输系统中使用；（ii）使用完整的器官进行验证测试，以证明其潜在商业化的有效性。