Liquid degradable aliphatic polycarbonate as an injectable drug delivery vehicle
作为注射给药载体的液体可降解脂肪族聚碳酸酯
基本信息
- 批准号:544503-2019
- 负责人:
- 金额:$ 9.11万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Idea to Innovation
- 财政年份:2019
- 资助国家:加拿大
- 起止时间:2019-01-01 至 2020-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Chronic pain afflicts over 100 million North Americans and the current treatments are only moderately effective. In particular, opioids are commonly subscribed for this purpose, which has resulted in widespread problems with abuse and addiction. Moreover, current common therapy requires daily oral administration, leading to potential issues of patient compliance, overdose, and abuse. The objective of the proposed work is development of an implantable non-opioid drug depot that provides at least 4 weeks of delivery at therapeutic levels. The drug candidate chosen for these studies is gabapentin enacarbil, which is used clinically to treat chronic neuropathic pain. The gabapentin will be incorporated into a novel polymer formulation, for which we have filed patent protection. Discussions with potential industrial partners has made it clear that a necessary next step in the commercial development of our polymer is an in vivo demonstration of efficacy. As such, we propose to demonstrate the ability of our new polymer formulation to provide suitable drug delivery in a rat model.
慢性疼痛困扰着超过1亿的北美人,目前的治疗方法只有中等效果。特别是,阿片类药物通常用于这一目的,导致滥用和成瘾问题普遍存在。此外,目前的常见疗法需要每日口服给药,导致患者依从性、过量和滥用的潜在问题。拟议工作的目标是开发一种可植入的非阿片类药物贮库,以治疗水平提供至少4周的递送。这些研究选择的候选药物是加巴喷丁enacarbil,它在临床上用于治疗慢性神经性疼痛。加巴喷丁将被纳入一种新的聚合物配方,我们已经申请了专利保护。与潜在工业合作伙伴的讨论表明,我们聚合物商业开发的下一步是体内功效证明。因此,我们建议证明我们的新聚合物制剂在大鼠模型中提供合适药物递送的能力。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Amsden, Brian其他文献
Anti-atherosclerotic peptide delivery from a photocrosslinkable biodegradable network
- DOI:
10.1016/j.ijpharm.2009.12.030 - 发表时间:
2010-03-30 - 期刊:
- 影响因子:5.8
- 作者:
Amsden, Brian;Qi, Bo - 通讯作者:
Qi, Bo
Synthesis and characterization of biodegradable networks providing saturated-solution prolonged delivery
- DOI:
10.1002/jps.21023 - 发表时间:
2008-02-01 - 期刊:
- 影响因子:3.8
- 作者:
Amsden, Brian;Misra, Gauri;Turner, Norma - 通讯作者:
Turner, Norma
Sustained release of bioactive therapeutic proteins from a biodegradable elastomeric device
- DOI:
10.1016/j.jconrel.2006.09.077 - 发表时间:
2007-01-22 - 期刊:
- 影响因子:10.8
- 作者:
Gu, Frank;Neufeld, Ronald;Amsden, Brian - 通讯作者:
Amsden, Brian
Maintenance of vascular endothelial growth factor and potentially other therapeutic proteins bioactivity during a photo-initiated free radical cross-linking reaction forming biodegradable elastomers
- DOI:
10.1016/j.ejpb.2006.08.006 - 发表时间:
2007-04-01 - 期刊:
- 影响因子:4.9
- 作者:
Gu, Frank;Neufeld, Ronald;Amsden, Brian - 通讯作者:
Amsden, Brian
Amsden, Brian的其他文献
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{{ truncateString('Amsden, Brian', 18)}}的其他基金
Aliphatic polycarbonates: building blocks for new biodegradable biomaterials
脂肪族聚碳酸酯:新型可生物降解生物材料的基础材料
- 批准号:
RGPIN-2020-05598 - 财政年份:2022
- 资助金额:
$ 9.11万 - 项目类别:
Discovery Grants Program - Individual
Cell culture suite
细胞培养套件
- 批准号:
RTI-2022-00275 - 财政年份:2021
- 资助金额:
$ 9.11万 - 项目类别:
Research Tools and Instruments
Aliphatic polycarbonates: building blocks for new biodegradable biomaterials
脂肪族聚碳酸酯:新型可生物降解生物材料的基础材料
- 批准号:
RGPIN-2020-05598 - 财政年份:2021
- 资助金额:
$ 9.11万 - 项目类别:
Discovery Grants Program - Individual
CONNECT! NSERC CREATE Program In Soft Connective Tissue Regeneration/Therapy
连接!
- 批准号:
465675-2015 - 财政年份:2020
- 资助金额:
$ 9.11万 - 项目类别:
Collaborative Research and Training Experience
Aliphatic polycarbonates: building blocks for new biodegradable biomaterials
脂肪族聚碳酸酯:新型可生物降解生物材料的基础材料
- 批准号:
RGPIN-2020-05598 - 财政年份:2020
- 资助金额:
$ 9.11万 - 项目类别:
Discovery Grants Program - Individual
Design of polymers and bioreactors in the development of a tissue engineering strategy for degenerative disc disease
退行性椎间盘疾病组织工程策略开发中的聚合物和生物反应器设计
- 批准号:
RGPIN-2015-05179 - 财政年份:2019
- 资助金额:
$ 9.11万 - 项目类别:
Discovery Grants Program - Individual
CONNECT! NSERC CREATE Program In Soft Connective Tissue Regeneration/Therapy
连接!
- 批准号:
465675-2015 - 财政年份:2019
- 资助金额:
$ 9.11万 - 项目类别:
Collaborative Research and Training Experience
Design of polymers and bioreactors in the development of a tissue engineering strategy for degenerative disc disease
退行性椎间盘疾病组织工程策略开发中的聚合物和生物反应器设计
- 批准号:
RGPIN-2015-05179 - 财政年份:2018
- 资助金额:
$ 9.11万 - 项目类别:
Discovery Grants Program - Individual
CONNECT! NSERC CREATE Program In Soft Connective Tissue Regeneration/Therapy
连接!
- 批准号:
465675-2015 - 财政年份:2018
- 资助金额:
$ 9.11万 - 项目类别:
Collaborative Research and Training Experience
CONNECT! NSERC CREATE Program In Soft Connective Tissue Regeneration/Therapy
连接!
- 批准号:
465675-2015 - 财政年份:2017
- 资助金额:
$ 9.11万 - 项目类别:
Collaborative Research and Training Experience
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