Urgent Replacement of 700 MHz NMR CryoPlatform

最多3000个字符 * 剩余字符：71** 急需所需的冷冻平台来维修和升级我们宝贵的700 MHz NMR光谱仪。为该设备提供的资金将恢复在催化、药物化学、能量收集、纳米技术和材料科学等各个领域进行高影响力发现和培训高素质人才的努力。冷冻探针700 MHz核磁共振光谱仪是一种重要的分析工具，在过去的12年里，在区域磁共振中心，冷冻探针700 MHz核磁共振光谱仪的运行时间为420至500小时/月，来自化学系（蒙特利尔大学）20多位教授实验室的200多名学生和博士后研究员（PDF）使用了该仪器。重要冷冻平台的组件于2019年8月失效。如果没有所要求的部件，700兆赫核磁共振波谱仪的灵敏度就会降低，无法满足最初购买这台160万美元机器的需要。此后，加拿大药物化学、催化和材料科学领导者实验室的研究被推迟，影响了针对药物发现、绿色制造和下一代太阳能电池和电池的多个跨学科合作项目。12名申请人包括冷冻探针700 MHz NMR光谱仪的所有主要用户。申请人目前监督115名学生，PDF和访问科学家，其中50%是女性，30%是明显的少数民族。冷冻平台的紧急维修对这些申请人至关重要，他们背负着沉重的负担，以维持生产力，并定期与多个外部合作者分享成果。年轻研究人员的职业生涯也陷入停滞，无法获得冷冻探针700 MHz NMR光谱，以推进化学糖组学和生物化学的研究，与ACS石油研究基金等机构的竞争资金。此外，冷冻平台故障已经危及来自其他学术和私营部门实验室的十几个客户的项目。配备冷冻探针的700 MHz NMR仪器是一种最先进的教学设备，用于在全球学术界和工业界进行当代研究所需的领域培训HQP。各种区域范围的学生项目依赖于冷冻探针700 MHz NMR光谱仪的高灵敏度来研究溶液中的少量复杂分子。恢复我们的冷冻探针700 MHz NMR光谱仪的全部功能是迫切需要的，以获得复杂分子结构的精确信息，以保持有价值的科学研究的稳定流动，培训HQP，并领导生物医药化学，绿色化学/催化和材料科学方面的合作项目，以确保加拿大的经济活力和高水平的生活。

3000 characters maximum ***Characters remaining:71******The requested cryoplatform is urgently needed to repair and upgrade our valuable 700 MHz NMR spectrometer. Funding for this equipment would restore efforts to make high impact discoveries and train highly qualified personnel (HQP) in various fields including catalysis, medicinal chemistry, energy harvesting, nanotechnology and materials science. An essential analytical tool that was used by >200 students and postdoctoral fellows (PDFs) from the laboratories of >20 professors in the Department of Chemistry (Université de Montréal), the cryoprobe 700 MHz NMR spectrometer has operated between 420 to 500 h/month over the past 12 years in the Regional Centre for Magnetic Resonance. Components of the essential cryoplatform failed in August 2019. Without the requested parts, the 700 MHz NMR spectrometer is less sensitive and incapable of serving the needs for which the $1.6 million machine was originally purchased. Research in the laboratories of Canadian leaders in medicinal chemistry, catalysis, and materials science has since been delayed, impacting upon multiple interdisciplinary collaborative projects targeted on drug discovery, green-manufacturing and next-generation solar cells and batteries. The 12 applicants include every primary user of the cryoprobe 700 MHz NMR spectrometer. The applicants supervise currently 115 students, PDFs and visiting scientists of which 50% are female and 30% are visible minorities. Urgent repair of the cryoplatform is critical to these applicants, who carry heavy burdens to sustain productivity and share results on a regular milestone basis with multiple external collaborators. Career trajectories of young investigators are also being stalled without access to cryoprobe 700 MHz NMR spectrocopy to advance research in chemical glycomics and photocatalysis, with competitive funding from agencies such as the ACS Petroleum Research Fund. Moreover, cryoplatform failure has jeopardized projects with over a dozen clients from outside the university in other academic and private sector laboratories. The cryoprobe-equipped 700 MHz NMR instrument has been a state-of-the-art teaching device for training HQP in an area required for contemporary research in academia and industry worldwide. Various region-wide student projects depend on the high sensitivity of the cryoprobe 700 MHz NMR spectrometer to study small quantities of complex molecules in solution. Restoration of the full functionality of our cryoprobe 700 MHz NMR spectrometer is urgently needed for procuring precise information on complex molecular structures to maintain a steady flow of valuable scientific research, to train HQP, and to lead collaborative projects in bio-medicinal chemistry, green chemistry/catalysis, and materials science needed to ensure economic vitality and a high standard of living in Canada.********