Liquid chromatography-mass spectrometry (LCMS) instrument

迫切需要所要求的液-色-质谱仪(LCMS)，以持续努力，在催化、药物化学、能源科学、纳米技术和环境研究等不同领域，在化学系(蒙大拿大)进行高影响力的发现和培训高素质人员。作为一种基本的分析工具，来自17个不同教授的实验室的200名学生和博士后研究员使用了以前的LCMS仪器，该仪器于2003年用CFI资金购买，安置在区域质谱学中心(RMSC-UM)，并作为一个开放访问的主力，我们的研究人员在操作和数据处理方面接受了十多年的全面培训。除了维修，迫切需要更换，现已停止使用的LCMS仪器也是RMSC-UM工作人员在其他学术和私营部门实验室为十几名来自大学以外的客户提供服务的基本工具。作为化学和生物化学中宝贵的技能集和不可或缺的研究技术，LC MS经常用于获得关于化合物组成和纯度的准确信息，以便及时做出继续/不继续的研究决策，优化反应条件，确保产品质量，并评估成分化学计量比。各种区域范围的学生项目都是以对微量样品进行有效分析所获得的信息为指导的，这是常规注入开放式LC MS仪器的结果。如果没有LC MS仪器，重要的研究将被推迟并受到影响，因为我们的替代开放式分析仪器在快速数据采集期间缺乏常规提供相同灵敏度和精度的能力，以指导对采用现代技术的研究进行明智的评估和执行，例如组合实验、固体支撑化学和固相微萃取。迫切需要一种开放获取的LC MS仪器，这对与学术界和工业界同事成功开展合作研究至关重要，他们等待用于生物研究的样品纯度的确认，并从环境、能源和材料科学的不同研究中寻求关于样品组成的信息。因此，更换这一重要的开放获取的LCMS仪器对于确保有价值的科学研究和培训的稳定流动，造福加拿大的医疗保健、经济和环境至关重要。

The requested liquid-chromatography-mass spectrometry (LCMS) instrument is urgently needed to sustain efforts to make high impact discoveries and train highly qualified personnel (HQP) at the Department of Chemistry (Université de Montréal, UM) in various fields including catalysis, medicinal chemistry, energy science, nanotechnology and environmental research. An essential analytical tool that was used by >200 students and postdoctoral fellows from the laboratories of 17 different professors, the former LCMS instrument was purchased with CFI funds in 2003, housed in the Regional Mass Spectrometry Centre (RMSC-UM), and served as an open-access workhorse on which our researchers were fully trained in operation and data handling for over a decade. Beyond repair, desperately needing replacement, the now defunct LCMS instrument was also an essential tool employed by RMSC-UM staff to service over a dozen clients from outside the university in other academic and private sector laboratories. A valuable skill set and indispensable research technique in chemistry and biochemistry, LCMS is routinely employed to obtain precise information on compound composition and purity for timely making go/no-go research decisions, to optimize reaction conditions, to ensure product quality, and to assess component stoichiometry. Various region-wide student projects are guided by information from efficient analysis of miniscule amounts of sample as a result of routine injection into an open-access LCMS instrument. Without the LCMS instrument, important research is being delayed and compromised because our alternative open-access analytical machines lack the capacity to routinely provide the same sensitivity and precision during rapid data acquisition to guide the judicious evaluation and execution of investigations employing modern techniques: e.g., combinatorial experimentation, solid-supported chemistry, and solid-phase micro extraction. Urgently needed, an open-access LCMS instrument is essential for the success of collaborative research with academic and industrial colleagues, who await validation of the purity of samples destined for biological studies, and who seek information on sample composition from diverse research in environment, energy and materials science. Replacement of this vital open-access LCMS instrument is thus critical to ensure a steady flow of valuable scientific research and training for the benefit of Canada's healthcare, economy and environment.*****